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UNIPROT:P43403 (18 hits)
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Pathway evidence source
Curated
inferred
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Index
T cell receptor signaling pathway
TCR signaling
Motif
Protein
Start
End
Switch Type
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Information
Evidence
T cell receptor signaling pathway
(
KEGG - hsa04660
)
LIG_TYR_ITAM
CD3E_HUMAN
185
202
Specificity
Altered binding specificity
Phosphorylation of
T-cell surface glycoprotein CD3 epsilon chain (CD3E)
by Lck (
Tyrosine-protein kinase Lck (LCK)
) during T cell activation switches the specificity of
CD3E
from SH3 domain containing proteins like
Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8L1)
to SH2 domain containing proteins like
Tyrosine-protein kinase ZAP-70 (ZAP70)
.
details
Inferred
LIG_TYR_ITAM
CD3Z_HUMAN
69
86
Avidity‑sensing
Phosphorylation of Y72 and Y83 in the ITAM motif of
T-cell surface glycoprotein CD3 zeta chain (CD247)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase ZAP-70 (ZAP70)
.
details
Curated
LIG_TYR_ITAM
CD3Z_HUMAN
69
86
Avidity‑sensing
Phosphorylation of Y72 and Y83 in the ITAM motif of
T-cell surface glycoprotein CD3 zeta chain (CD247)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase ZAP-70 (ZAP70)
.
details
Curated
LIG_TYR_ITAM
CD3Z_HUMAN
108
126
Avidity‑sensing
Phosphorylation of Y111 and Y123 in the ITAM motif of
T-cell surface glycoprotein CD3 zeta chain (CD247)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase ZAP-70 (ZAP70)
.
details
Curated
LIG_TYR_ITAM
CD3Z_HUMAN
108
126
Avidity‑sensing
Phosphorylation of Y111 and Y123 in the ITAM motif of
T-cell surface glycoprotein CD3 zeta chain (CD247)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase ZAP-70 (ZAP70)
.
details
Curated
LIG_TYR_ITAM
CD3Z_HUMAN
139
156
Avidity‑sensing
Phosphorylation of Y142 and Y153 in the ITAM motif of
T-cell surface glycoprotein CD3 zeta chain (CD247)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase ZAP-70 (ZAP70)
.
details
Curated
LIG_TYR_ITAM
CD3Z_HUMAN
139
156
Avidity‑sensing
Phosphorylation of Y142 and Y153 in the ITAM motif of
T-cell surface glycoprotein CD3 zeta chain (CD247)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase ZAP-70 (ZAP70)
.
details
Curated
LIG_TYR_ITAM
CD3G_HUMAN
157
174
Avidity‑sensing
Phosphorylation of Y160 and Y171 in the ITAM motif of
T-cell surface glycoprotein CD3 gamma chain (CD3G)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase ZAP-70 (ZAP70)
.
details
Curated
LIG_TYR_ITAM
CD3G_HUMAN
157
174
Avidity‑sensing
Phosphorylation of Y160 and Y171 in the ITAM motif of
T-cell surface glycoprotein CD3 gamma chain (CD3G)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase ZAP-70 (ZAP70)
.
details
Curated
LIG_SH2_IIC
ZAP70_HUMAN
284
300
Binary
Physicochemical compatibility
Phosphorylation of Y292 in the SH2-binding motif of
Tyrosine-protein kinase ZAP-70 (ZAP70)
induces binding to the
E3 ubiquitin-protein ligase CBL-B (CBLB)
protein.
details
Inferred
TCR signaling
(
Reactome - 202403
)
LIG_TYR_ITAM
CD3Z_HUMAN
69
86
Avidity‑sensing
Phosphorylation of Y72 and Y83 in the ITAM motif of
T-cell surface glycoprotein CD3 zeta chain (CD247)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase ZAP-70 (ZAP70)
.
details
Curated
LIG_TYR_ITAM
CD3Z_HUMAN
69
86
Avidity‑sensing
Phosphorylation of Y72 and Y83 in the ITAM motif of
T-cell surface glycoprotein CD3 zeta chain (CD247)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase ZAP-70 (ZAP70)
.
details
Curated
LIG_TYR_ITAM
CD3Z_HUMAN
108
126
Avidity‑sensing
Phosphorylation of Y111 and Y123 in the ITAM motif of
T-cell surface glycoprotein CD3 zeta chain (CD247)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase ZAP-70 (ZAP70)
.
details
Curated
LIG_TYR_ITAM
CD3Z_HUMAN
108
126
Avidity‑sensing
Phosphorylation of Y111 and Y123 in the ITAM motif of
T-cell surface glycoprotein CD3 zeta chain (CD247)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase ZAP-70 (ZAP70)
.
details
Curated
LIG_TYR_ITAM
CD3Z_HUMAN
139
156
Avidity‑sensing
Phosphorylation of Y142 and Y153 in the ITAM motif of
T-cell surface glycoprotein CD3 zeta chain (CD247)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase ZAP-70 (ZAP70)
.
details
Curated
LIG_TYR_ITAM
CD3Z_HUMAN
139
156
Avidity‑sensing
Phosphorylation of Y142 and Y153 in the ITAM motif of
T-cell surface glycoprotein CD3 zeta chain (CD247)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase ZAP-70 (ZAP70)
.
details
Curated
LIG_TYR_ITAM
CD3G_HUMAN
157
174
Avidity‑sensing
Phosphorylation of Y160 and Y171 in the ITAM motif of
T-cell surface glycoprotein CD3 gamma chain (CD3G)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase ZAP-70 (ZAP70)
.
details
Curated
LIG_TYR_ITAM
CD3G_HUMAN
157
174
Avidity‑sensing
Phosphorylation of Y160 and Y171 in the ITAM motif of
T-cell surface glycoprotein CD3 gamma chain (CD3G)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase ZAP-70 (ZAP70)
.
details
Curated
