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Group by :Switch typeMotif classProteinEnzymePathway            Group Index    Colouring Info              Filtered: ELM:TRG_NES (10 hits) x
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  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
  Uncategorised  Rheostatic  Allostery  Avidity-sensing
  Physicochemical compatibility  Pre-translational  Competition

x  Index
Catenin delta-1Cellular tumor antigen p53E3 ubiquitin-protein ligase Mdm2
F-box/WD repeat-containing protein 7M-phase inducer phosphatase 3Metallothionein expression activator (Saccharomyces)
Mothers against decapentaplegic homolog 4Nuclear factor erythroid 2-related factor 1Protein PML


MotifStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

Catenin delta-1 - CTNND1 -  Homo sapiens
TRG_NES_CRM1_1942956BinaryPre‑translationalAlternative splicing removes the nuclear export signal (NES) of Catenin delta-1 (CTNND1), abrogating binding to Exportin-1 (XPO1). Despite demonstration of the importance of the NES for removing Catenin delta-1 (CTNND1) from the nucleus, those isoforms without NES are rarely found in the nucleus.
details

Cellular tumor antigen p53 - TP53 -  Homo sapiens
TRG_NES_CRM1_1339352BinaryPre‑translationalAlternative splicing removes the nuclear export signal (NES) of Cellular tumor antigen p53 (TP53), abrogating binding to Exportin-1 (XPO1) and export from the nucleus.
details

E3 ubiquitin-protein ligase Mdm2 - MDM2 -  Homo sapiens
TRG_NES_CRM1_2190202BinaryPre‑translationalAlternative splicing removes the nuclear export signal (NES) of E3 ubiquitin-protein ligase Mdm2 (MDM2), abrogating binding to Exportin-1 (XPO1).
details

F-box/WD repeat-containing protein 7 - FBXW7 -  Homo sapiens
TRG_NES_CRM1_21926BinaryPre‑translationalAlternative splicing removes the nuclear export signal (NES) of Isoform Archipelago beta of F-box/WD repeat-containing protein 7 (FBXW7), abrogating binding to Exportin-1 (XPO1) and export from nucleus. The presence of the NES produces an isoform with a cytoplasmic localisation. The two other isoforms of FBXW7 localise to the nucleus and the nucleolus, respectively.
details

M-phase inducer phosphatase 3 - CDC25C -  Homo sapiens
TRG_NES_CRM1_1189203BinaryPhysicochemical compatibilityPhosphorylation of S198 in the NES of M-phase inducer phosphatase 3 (CDC25C) by Serine/threonine-protein kinase PLK1 (PLK1) inhibits binding to Exportin-1 (XPO1), thus promoting nuclear localization of M-phase inducer phosphatase 3 (CDC25C).
details

Metallothionein expression activator - ACE2 -  Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
TRG_NES122150BinaryPhysicochemical compatibilityPhosphorylation of S137 in the NES of Metallothionein expression activator (ACE2) inhibits binding to Exportin-1 (CRM1). Phosphorylation of S137, and to a lesser extent S122, by Cbk1 directly antagonizes the interaction of Ace2 with nuclear export machinery.
details
TRG_NES122150BinaryPhysicochemical compatibilityPhosphorylation of S122 in the NES of Metallothionein expression activator (ACE2) inhibits binding to Exportin-1 (CRM1). Phosphorylation of S137, and to a lesser extent S122, by Cbk1 directly antagonizes the interaction of Ace2 with nuclear export machinery.
details

Mothers against decapentaplegic homolog 4 - SMAD4 -  Homo sapiens
TRG_NES_CRM1_2142149BinaryPre‑translationalAlternative splicing removes the nuclear export signal (NES) motif of Mothers against decapentaplegic homolog 4 (SMAD4), thereby inhibiting binding to Exportin-1 (XPO1) and export from the nucleus. A splice variant lacking the NES does not shuttle back and forth between nucleus and cytosol. At present, this particular splice variant is not annotated in UniProtKB.
details

Nuclear factor erythroid 2-related factor 1 - NFE2L1 -  Homo sapiens
TRG_NES_CRM1_2251259BinaryPre‑translationalAlternative splicing removes the nuclear export signal (NES) of Nuclear factor erythroid 2-related factor 1 (NFE2L1), abrogating binding to Exportin-1 (XPO1). Only the full-length variant of NFE2L1 (Isoform 1 of Nuclear factor erythroid 2-related factor 1 (NFE2L1)) contains an NES and shows cytoplasmic localisation. The two other naturally occuring isoforms (of which at present only 1 is annotated in UniProtKB) lack the NES and show exclusive nuclear staining.
details

Protein PML - PML -  Homo sapiens
TRG_NES_CRM1_1702716BinaryPre‑translationalAlternative splicing removes the nuclear export signal (NES) of Protein PML (PML), abrogating binding to Exportin-1 (XPO1) and export from the nucleus.
details
           
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