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Group by :Switch typeMotif classProteinEnzymePathway            Group Index    Colouring Info              Filtered: UNIPROT:Q06124 (12 hits) x
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  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
  Uncategorised  Rheostatic  Allostery  Avidity-sensing
  Physicochemical compatibility  Pre-translational  Competition

x  Index
Fibroblast growth factor receptor substrate 2Growth hormone receptorInterleukin-4 receptor subunit alpha
Orexin receptor type 1Signaling lymphocytic activation moleculeTrem-like transcript 1 protein


MotifStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

Fibroblast growth factor receptor substrate 2 - FRS2 -  Homo sapiens
LIG_SH2_IIA431440BinaryPhysicochemical compatibilityPhosphorylation of Y436 in the SH2-binding motif of Fibroblast growth factor receptor substrate 2 (FRS2) induces binding to the Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) protein.
details
LIG_SH2_IIA465475BinaryPhysicochemical compatibilityPhosphorylation of Y471 in the SH2-binding motif of Fibroblast growth factor receptor substrate 2 (FRS2) induces binding to the Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) protein.
details

Growth hormone receptor - GHR -  Homo sapiens
LIG_SH2_IIA591600BinaryPhysicochemical compatibilityPhosphorylation of Y595 in the SH2-binding motif of Growth hormone receptor (GHR) induces binding to the Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) protein.
details

Interleukin-4 receptor subunit alpha - IL4R -  Homo sapiens
LIG_SH2_IIA706721BinaryPhysicochemical compatibilityPhosphorylation of Y713 in the SH2-binding motif of Interleukin-4 receptor subunit alpha (IL4R) induces binding to the Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) protein.
details

Orexin receptor type 1 - HCRTR1 -  Homo sapiens
LIG_TYR_ITSM7986Avidity‑sensingOrexin-A induced phosphorylation of the ITSM and ITIM motifs in Orexin receptor type 1 (HCRTR1) allows binding of Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) via its two SH2 domains. Mutation of either tyrosine in the motifs abolishes binding of Tyrosine-protein phosphatase non-receptor type 11 (PTPN11).
details
LIG_TYR_ITIM356361Avidity‑sensingOrexin-A induced phosphorylation of the ITSM and ITIM motifs in Orexin receptor type 1 (HCRTR1) allows binding of Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) via its two SH2 domains. Mutation of either tyrosine in the motifs abolishes binding of Tyrosine-protein phosphatase non-receptor type 11 (PTPN11).
details
LIG_TYR_ITSM7986Avidity‑sensingOrexin-A induced phosphorylation of the ITSM and ITIM motifs in Orexin receptor type 1 (HCRTR1) allows binding of Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) via its two SH2 domains. Mutation of either tyrosine in the motifs abolishes binding of Tyrosine-protein phosphatase non-receptor type 11 (PTPN11).
details
LIG_TYR_ITIM356361Avidity‑sensingOrexin-A induced phosphorylation of the ITSM and ITIM motifs in Orexin receptor type 1 (HCRTR1) allows binding of Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) via its two SH2 domains. Mutation of either tyrosine in the motifs abolishes binding of Tyrosine-protein phosphatase non-receptor type 11 (PTPN11).
details

Signaling lymphocytic activation molecule - SLAMF1 -  Homo sapiens
LIG_TYR_ITSM277284BinaryPhysicochemical compatibilityPhosphorylation of Y281 in the ITSM motif of Signaling lymphocytic activation molecule (SLAMF1) induces binding of Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) via one of its SH2 domains.
details
LIG_TYR_ITSM323330BinaryPhysicochemical compatibilityPhosphorylation of Y327 in the ITSM motif of Signaling lymphocytic activation molecule (SLAMF1) induces binding of Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) via one of its SH2 domains.
details

Trem-like transcript 1 protein - TREML1 -  Homo sapiens
LIG_TYR_ITIM279284BinaryPre‑translationalAlternative splicing removes the ITIM (immunoreceptor tyrosine-based inhibitory motif) of Trem-like transcript 1 protein (TREML1), abrogating binding to Tyrosine-protein phosphatase non-receptor type 11 (PTPN11).
details
LIG_TYR_ITIM279284BinaryPre‑translationalAlternative splicing removes the ITIM (immunoreceptor tyrosine-based inhibitory motif) of Trem-like transcript 1 protein (TREML1), abrogating binding to Tyrosine-protein phosphatase non-receptor type 11 (PTPN11).
details
           
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