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ELM:LIG_TYR_ITAM (42 hits)
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Modifier evidence source
Curated
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Index
Tyrosine-protein kinase Blk
Tyrosine-protein kinase Fyn
Tyrosine-protein kinase Fyn
(Mus)
Tyrosine-protein kinase Lck
Tyrosine-protein kinase Lyn
Tyrosine-protein kinase Lyn
(Mus)
Tyrosine-protein kinase SYK
Motif
Protein
Start
End
Switch Type
Switch Subtype
Switch description
Information
Evidence
Tyrosine-protein kinase Blk -
BLK
-
Homo sapiens
LIG_TYR_ITAM
FCG2A_HUMAN
285
307
Avidity‑sensing
Phosphorylation of Y288 and Y304 in the ITAM motif of
Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (SYK)
.
details
Inferred
LIG_TYR_ITAM
FCG2A_HUMAN
285
307
Avidity‑sensing
Phosphorylation of Y288 and Y304 in the ITAM motif of
Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (SYK)
.
details
Inferred
LIG_TYR_ITAM
FCG2A_HUMAN
285
307
Avidity‑sensing
Phosphorylation of Y288 and Y304 in the ITAM motif of
Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (SYK)
.
details
Inferred
LIG_TYR_ITAM
FCG2A_HUMAN
285
307
Avidity‑sensing
Phosphorylation of Y288 and Y304 in the ITAM motif of
Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (SYK)
.
details
Inferred
LIG_TYR_ITAM
FCG2A_HUMAN
285
307
Avidity‑sensing
Phosphorylation of Y288 and Y304 in the ITAM motif of
Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (SYK)
.
details
Inferred
LIG_TYR_ITAM
FCG2A_HUMAN
285
307
Avidity‑sensing
Phosphorylation of Y288 and Y304 in the ITAM motif of
Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (SYK)
.
details
Inferred
LIG_TYR_ITAM
FCG2A_HUMAN
285
307
Avidity‑sensing
Phosphorylation of Y288 and Y304 in the ITAM motif of
Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (SYK)
.
details
Inferred
LIG_TYR_ITAM
FCG2A_HUMAN
285
307
Avidity‑sensing
Phosphorylation of Y288 and Y304 in the ITAM motif of
Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (SYK)
.
details
Inferred
Tyrosine-protein kinase Fyn -
FYN
-
Homo sapiens
LIG_TYR_ITAM
CD3E_HUMAN
185
202
Specificity
Altered binding specificity
Phosphorylation of
T-cell surface glycoprotein CD3 epsilon chain (CD3E)
by Lck (
Tyrosine-protein kinase Lck (LCK)
) during T cell activation switches the specificity of
CD3E
from SH3 domain containing proteins like
Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8L1)
to SH2 domain containing proteins like
Tyrosine-protein kinase ZAP-70 (ZAP70)
.
details
Inferred
LIG_TYR_ITAM
CD3E_HUMAN
185
202
Specificity
Altered binding specificity
Phosphorylation of
T-cell surface glycoprotein CD3 epsilon chain (CD3E)
by Lck (
Tyrosine-protein kinase Lck (LCK)
) during T cell activation switches the specificity of
CD3E
from SH3 domain containing proteins like
Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8L1)
to SH2 domain containing proteins like
Tyrosine-protein kinase ZAP-70 (ZAP70)
.
details
Inferred
LIG_TYR_ITAM
CD3E_HUMAN
185
202
Avidity‑sensing
Phosphorylation of Y188 and Y199 in the ITAM motif of
T-cell surface glycoprotein CD3 epsilon chain (CD3E)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (SYK)
.
details
Inferred
LIG_TYR_ITAM
CD3E_HUMAN
185
202
Avidity‑sensing
Phosphorylation of Y188 and Y199 in the ITAM motif of
T-cell surface glycoprotein CD3 epsilon chain (CD3E)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (SYK)
.
details
Inferred
LIG_TYR_ITAM
CD3E_HUMAN
185
202
Avidity‑sensing
Phosphorylation of Y188 and Y199 in the ITAM motif of
T-cell surface glycoprotein CD3 epsilon chain (CD3E)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (SYK)
.
details
Inferred
LIG_TYR_ITAM
CD3E_HUMAN
185
202
Avidity‑sensing
Phosphorylation of Y188 and Y199 in the ITAM motif of
T-cell surface glycoprotein CD3 epsilon chain (CD3E)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (SYK)
.
details
Inferred
LIG_TYR_ITAM
CD3Z_HUMAN
108
126
Avidity‑sensing
Phosphorylation of Y111 and Y123 in the ITAM motif of
T-cell surface glycoprotein CD3 zeta chain (CD247)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase ZAP-70 (ZAP70)
.
details
Inferred
LIG_TYR_ITAM
CD3Z_HUMAN
108
126
Avidity‑sensing
Phosphorylation of Y111 and Y123 in the ITAM motif of
T-cell surface glycoprotein CD3 zeta chain (CD247)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase ZAP-70 (ZAP70)
.
details
Inferred
LIG_TYR_ITAM
CD3Z_HUMAN
108
126
Avidity‑sensing
Phosphorylation of Y111 and Y123 in the ITAM motif of
T-cell surface glycoprotein CD3 zeta chain (CD247)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase ZAP-70 (ZAP70)
.
details
Inferred
LIG_TYR_ITAM
CD3Z_HUMAN
108
126
Avidity‑sensing
Phosphorylation of Y111 and Y123 in the ITAM motif of
T-cell surface glycoprotein CD3 zeta chain (CD247)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase ZAP-70 (ZAP70)
.
details
Inferred
LIG_TYR_ITAM
FCG2A_HUMAN
285
307
Avidity‑sensing
Phosphorylation of Y288 and Y304 in the ITAM motif of
Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (SYK)
.
details
Inferred
LIG_TYR_ITAM
FCG2A_HUMAN
285
307
Avidity‑sensing
Phosphorylation of Y288 and Y304 in the ITAM motif of
Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (SYK)
.
details
Inferred
LIG_TYR_ITAM
FCG2A_HUMAN
285
307
Avidity‑sensing
Phosphorylation of Y288 and Y304 in the ITAM motif of
Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (SYK)
.
details
Inferred
LIG_TYR_ITAM
FCG2A_HUMAN
285
307
Avidity‑sensing
Phosphorylation of Y288 and Y304 in the ITAM motif of
Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (SYK)
.
details
Inferred
LIG_TYR_ITAM
FCG2A_HUMAN
285
307
Avidity‑sensing
Phosphorylation of Y288 and Y304 in the ITAM motif of
Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (SYK)
.
details
Inferred
LIG_TYR_ITAM
FCG2A_HUMAN
285
307
Avidity‑sensing
Phosphorylation of Y288 and Y304 in the ITAM motif of
Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (SYK)
.
details
Inferred
Tyrosine-protein kinase Fyn -
FYN
-
Mus musculus
LIG_TYR_ITAM
FCG2A_HUMAN
285
307
Avidity‑sensing
Phosphorylation of Y288 and Y304 in the ITAM motif of
Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (SYK)
.
details
Inferred
LIG_TYR_ITAM
FCG2A_HUMAN
285
307
Avidity‑sensing
Phosphorylation of Y288 and Y304 in the ITAM motif of
Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (SYK)
.
details
Inferred
Tyrosine-protein kinase Lck -
LCK
-
Homo sapiens
LIG_TYR_ITAM
CD3Z_HUMAN
139
156
Avidity‑sensing
Phosphorylation of Y142 and Y153 in the ITAM motif of
T-cell surface glycoprotein CD3 zeta chain (CD247)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase ZAP-70 (ZAP70)
.
details
Inferred
LIG_TYR_ITAM
CD3Z_HUMAN
139
156
Avidity‑sensing
Phosphorylation of Y142 and Y153 in the ITAM motif of
T-cell surface glycoprotein CD3 zeta chain (CD247)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase ZAP-70 (ZAP70)
.
details
Inferred
Tyrosine-protein kinase Lyn -
LYN
-
Homo sapiens
LIG_TYR_ITAM
FCG2A_HUMAN
285
307
Avidity‑sensing
Phosphorylation of Y288 and Y304 in the ITAM motif of
Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (SYK)
.
details
Inferred
LIG_TYR_ITAM
FCG2A_HUMAN
285
307
Avidity‑sensing
Phosphorylation of Y288 and Y304 in the ITAM motif of
Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (SYK)
.
details
Inferred
LIG_TYR_ITAM
FCG2A_HUMAN
285
307
Avidity‑sensing
Phosphorylation of Y288 and Y304 in the ITAM motif of
Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (SYK)
.
details
Inferred
LIG_TYR_ITAM
FCG2A_HUMAN
285
307
Avidity‑sensing
Phosphorylation of Y288 and Y304 in the ITAM motif of
Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (SYK)
.
details
Inferred
LIG_TYR_ITAM
FCG2A_HUMAN
285
307
Avidity‑sensing
Phosphorylation of Y288 and Y304 in the ITAM motif of
Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (SYK)
.
details
Inferred
LIG_TYR_ITAM
FCG2A_HUMAN
285
307
Avidity‑sensing
Phosphorylation of Y288 and Y304 in the ITAM motif of
Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (SYK)
.
details
Inferred
Tyrosine-protein kinase Lyn -
LYN
-
Mus musculus
LIG_TYR_ITAM
FCG2A_HUMAN
285
307
Avidity‑sensing
Phosphorylation of Y288 and Y304 in the ITAM motif of
Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (SYK)
.
details
Inferred
LIG_TYR_ITAM
FCG2A_HUMAN
285
307
Avidity‑sensing
Phosphorylation of Y288 and Y304 in the ITAM motif of
Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (SYK)
.
details
Inferred
Tyrosine-protein kinase SYK -
SYK
-
Homo sapiens
LIG_TYR_ITAM
FCG2A_HUMAN
285
307
Avidity‑sensing
Phosphorylation of Y288 and Y304 in the ITAM motif of
Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (SYK)
.
details
Inferred
LIG_TYR_ITAM
FCG2A_HUMAN
285
307
Avidity‑sensing
Phosphorylation of Y288 and Y304 in the ITAM motif of
Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (SYK)
.
details
Inferred
LIG_TYR_ITAM
FCG2A_HUMAN
285
307
Avidity‑sensing
Phosphorylation of Y288 and Y304 in the ITAM motif of
Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (SYK)
.
details
Inferred
LIG_TYR_ITAM
FCG2A_HUMAN
285
307
Avidity‑sensing
Phosphorylation of Y288 and Y304 in the ITAM motif of
Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (SYK)
.
details
Inferred
LIG_TYR_ITAM
FCG2A_HUMAN
285
307
Avidity‑sensing
Phosphorylation of Y288 and Y304 in the ITAM motif of
Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (SYK)
.
details
Inferred
LIG_TYR_ITAM
FCG2A_HUMAN
285
307
Avidity‑sensing
Phosphorylation of Y288 and Y304 in the ITAM motif of
Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (SYK)
.
details
Inferred
