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| Domain hiding | Altered binding specificity | Motif hiding | Composite binding site formation |
| Uncategorised | Rheostatic | Allostery | Avidity-sensing |
| Physicochemical compatibility | Pre-translational | Competition |
| Protein | Start | End | Switch Type | Switch Subtype | Switch Description | Information |
LIG_ALG2 - | |||||||
| PDC6I_HUMAN | 801 | 810 | Binary | Allostery | Binding of calcium(2+) to Programmed cell death protein 6 (PDCD6) opens a hydrophobic pocket on Programmed cell death protein 6 (PDCD6) that is required for binding of Programmed cell death 6-interacting protein (PDCD6IP). | ||
LIG_IQ - Calmodulin binding helical peptide motif | |||||||
| S61A1_CANFA | 13 | 31 | Binary | Allostery | Binding of calcium(2+) to Calmodulin (Calm1) exposes a binding site on Calmodulin (Calm1) for the Calmodulin-binding IQ motif of Protein transport protein Sec61 subunit alpha isoform 1 (SEC61A1), an interaction that results in closure of the protein-conducting channel located in the ER. | ||
| CAC1D_RAT | 1650 | 1669 | Binary | Pre‑translational | Alternative splicing removes the IQ motif of Voltage-dependent L-type calcium channel subunit alpha-1D (Cacna1d) abrogating binding to Calmodulin (Calm1). CaV1.3IQdelta (IQ-deleted Isoform CACN4B of Voltage-dependent L-type calcium channel subunit alpha-1D (Cacna1d)) channels exhibit a lack of calcium-dependent inactivation. CaV1.3IQdelta channel immunoreactivity was preferentially localised to cochlear outer hair cells (OHCs), whereas that of CaV1.3IQfull channels (IQ-possessing Isoform CACN4A of Voltage-dependent L-type calcium channel subunit alpha-1D (Cacna1d)) labelled inner hair cells (IHCs). | ||
| S61A1_CANFA | 13 | 31 | Binary | Allostery | Binding of calcium(2+) to Calmodulin (Calm1) exposes a binding site on Calmodulin (Calm1) for the Calmodulin-binding IQ motif of Protein transport protein Sec61 subunit alpha isoform 1 (SEC61A1), an interaction that results in closure of the protein-conducting channel located in the ER. | ||
LIG_IQ_2 - | |||||||
| AT2B1_HUMAN | 1114 | 1128 | Binary | Pre‑translational | Alternative splicing partially removes the IQ motif of Isoform CI of Plasma membrane calcium-transporting ATPase 1 (ATP2B1), partially inhibiting binding to Calmodulin (CALM1). | ||
| AT2B1_HUMAN | 1114 | 1128 | Binary | Pre‑translational | Alternative splicing partially removes the IQ motif of Isoform CI of Plasma membrane calcium-transporting ATPase 1 (ATP2B1), partially inhibiting binding to Calmodulin (CALM1). | ||