About Help Definitions Submit Search Analyse Browse Home


Group by :Switch typeMotif classProteinEnzymePathway            Group Index    Colouring Info              Filtered: PFAM:PF13499 (6 hits) x
submit


x  Coloured by switch type.
  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
  Uncategorised  Rheostatic  Allostery  Avidity-sensing
  Physicochemical compatibility  Pre-translational  Competition

x  Index
Plasma membrane calcium-transporting ATPase 1Programmed cell death 6-interacting proteinProtein transport protein Sec61 subunit alpha isoform 1 (Canis)
Voltage-dependent L-type calcium channel subunit alpha-1D (Rattus)


MotifStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

Plasma membrane calcium-transporting ATPase 1 - ATP2B1 -  Homo sapiens
LIG_IQ_211141128BinaryPre‑translationalAlternative splicing partially removes the IQ motif of Isoform CI of Plasma membrane calcium-transporting ATPase 1 (ATP2B1), partially inhibiting binding to Calmodulin (CALM1).
details
LIG_IQ_211141128BinaryPre‑translationalAlternative splicing partially removes the IQ motif of Isoform CI of Plasma membrane calcium-transporting ATPase 1 (ATP2B1), partially inhibiting binding to Calmodulin (CALM1).
details

Programmed cell death 6-interacting protein - PDCD6IP -  Homo sapiens
LIG_ALG2801810BinaryAllosteryBinding of calcium(2+) to Programmed cell death protein 6 (PDCD6) opens a hydrophobic pocket on Programmed cell death protein 6 (PDCD6) that is required for binding of Programmed cell death 6-interacting protein (PDCD6IP).
details

Protein transport protein Sec61 subunit alpha isoform 1 - SEC61A1 -  Canis familiaris
LIG_IQ1331BinaryAllosteryBinding of calcium(2+) to Calmodulin (Calm1) exposes a binding site on Calmodulin (Calm1) for the Calmodulin-binding IQ motif of Protein transport protein Sec61 subunit alpha isoform 1 (SEC61A1), an interaction that results in closure of the protein-conducting channel located in the ER.
details
LIG_IQ1331BinaryAllosteryBinding of calcium(2+) to Calmodulin (Calm1) exposes a binding site on Calmodulin (Calm1) for the Calmodulin-binding IQ motif of Protein transport protein Sec61 subunit alpha isoform 1 (SEC61A1), an interaction that results in closure of the protein-conducting channel located in the ER.
details

Voltage-dependent L-type calcium channel subunit alpha-1D - Cacna1d -  Rattus norvegicus
LIG_IQ16501669BinaryPre‑translationalAlternative splicing removes the IQ motif of Voltage-dependent L-type calcium channel subunit alpha-1D (Cacna1d) abrogating binding to Calmodulin (Calm1). CaV1.3IQdelta (IQ-deleted Isoform CACN4B of Voltage-dependent L-type calcium channel subunit alpha-1D (Cacna1d)) channels exhibit a lack of calcium-dependent inactivation. CaV1.3IQdelta channel immunoreactivity was preferentially localised to cochlear outer hair cells (OHCs), whereas that of CaV1.3IQfull channels (IQ-possessing Isoform CACN4A of Voltage-dependent L-type calcium channel subunit alpha-1D (Cacna1d)) labelled inner hair cells (IHCs).
details
           
Please send any suggestions/comments to: switches@elm.eu.org