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Group by :Switch typeMotif classProteinEnzymePathway            Group Index    Colouring Info              Filtered: UNIPROT:P12931 (5 hits) x
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  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
  Uncategorised  Rheostatic  Allostery  Avidity-sensing
  Physicochemical compatibility  Pre-translational  Competition

x  Index
LIG_SH2_IALIG_SH2_SRCLIG_SH3_2
TRG_ENDOCYTIC_2


ProteinStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

LIG_SH2_IA -
GBLP_RAT241250BinaryPhysicochemical compatibilityPhosphorylation of Y246 in the SH2-binding motif of Guanine nucleotide-binding protein subunit beta-2-like 1 (Gnb2l1) induces binding to the Proto-oncogene tyrosine-protein kinase Src (SRC) protein.
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LIG_SH2_SRC - Src-family Src Homology 2 (SH2) domains binding motif.
SRC_HUMAN530533BinaryPhysicochemical compatibilityPhosphorylation of Y530 in the SH2-binding motif of Proto-oncogene tyrosine-protein kinase Src (SRC) induces an intramolecular interaction with the SH2 domain of Proto-oncogene tyrosine-protein kinase Src (SRC) resulting in inhibition of its activity and preventing intermolecular interactions of its SH2 domain.
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LIG_SH3_2 - This is the motif recognized by class II SH3 domains
ADA15_HUMAN767772BinaryPre‑translationalAlternative splicing removes the SH3-binding motif of Disintegrin and metalloproteinase domain-containing protein 15 (ADAM15), abrogating binding to Proto-oncogene tyrosine-protein kinase Src (SRC). The overexpression of this splice variant has been linked to clinical aggressiveness of breast cancer.
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TRG_ENDOCYTIC_2 - Tyrosine-based sorting signal responsible for the interaction with mu subunit of AP (Adaptor Protein) complex
L1CAM_HUMAN11761179BinaryPhysicochemical compatibilityPhosphorylation of Y1176 by Proto-oncogene tyrosine-protein kinase Src (SRC) in the endocytosis motif of Neural cell adhesion molecule L1 (L1CAM) inhibits binding to AP-2 complex subunit mu (AP2M1).
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L1CAM_HUMAN11761179BinaryPhysicochemical compatibilityPhosphorylation of Y1176 in the endocytotic motif of Neural cell adhesion molecule L1 (L1CAM) by Proto-oncogene tyrosine-protein kinase Src (SRC) abolishes binding to the AP-2 complex subunit mu (AP2M1) and thereby inhibits internalisation of Neural cell adhesion molecule L1 (L1CAM).
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