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Group by :Switch typeMotif classProteinEnzymePathway            Group Index    Colouring Info              Filtered: UNIPROT:P12931 (5 hits) x
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  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
  Uncategorised  Rheostatic  Allostery  Avidity-sensing
  Physicochemical compatibility  Pre-translational  Competition

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Disintegrin and metalloproteinase domain-containing protein 15Guanine nucleotide-binding protein subunit beta-2-like 1 (Rattus)Neural cell adhesion molecule L1
Proto-oncogene tyrosine-protein kinase Src


MotifStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

Disintegrin and metalloproteinase domain-containing protein 15 - ADAM15 -  Homo sapiens
LIG_SH3_2767772BinaryPre‑translationalAlternative splicing removes the SH3-binding motif of Disintegrin and metalloproteinase domain-containing protein 15 (ADAM15), abrogating binding to Proto-oncogene tyrosine-protein kinase Src (SRC). The overexpression of this splice variant has been linked to clinical aggressiveness of breast cancer.
details

Guanine nucleotide-binding protein subunit beta-2-like 1 - Gnb2l1 -  Rattus norvegicus
LIG_SH2_IA241250BinaryPhysicochemical compatibilityPhosphorylation of Y246 in the SH2-binding motif of Guanine nucleotide-binding protein subunit beta-2-like 1 (Gnb2l1) induces binding to the Proto-oncogene tyrosine-protein kinase Src (SRC) protein.
details

Neural cell adhesion molecule L1 - L1CAM -  Homo sapiens
TRG_ENDOCYTIC_211761179BinaryPhysicochemical compatibilityPhosphorylation of Y1176 by Proto-oncogene tyrosine-protein kinase Src (SRC) in the endocytosis motif of Neural cell adhesion molecule L1 (L1CAM) inhibits binding to AP-2 complex subunit mu (AP2M1).
details
TRG_ENDOCYTIC_211761179BinaryPhysicochemical compatibilityPhosphorylation of Y1176 in the endocytotic motif of Neural cell adhesion molecule L1 (L1CAM) by Proto-oncogene tyrosine-protein kinase Src (SRC) abolishes binding to the AP-2 complex subunit mu (AP2M1) and thereby inhibits internalisation of Neural cell adhesion molecule L1 (L1CAM).
details

Proto-oncogene tyrosine-protein kinase Src - SRC -  Homo sapiens
LIG_SH2_SRC530533BinaryPhysicochemical compatibilityPhosphorylation of Y530 in the SH2-binding motif of Proto-oncogene tyrosine-protein kinase Src (SRC) induces an intramolecular interaction with the SH2 domain of Proto-oncogene tyrosine-protein kinase Src (SRC) resulting in inhibition of its activity and preventing intermolecular interactions of its SH2 domain.
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