switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: ELM:LIG_SH2_GRB2 (13 hits) x

x Coloured by: Pathway evidence source
Curated inferred

x Index

ErbB signaling pathway	Fc epsilon RI signaling pathway	Insulin signaling pathway
Natural killer cell mediated cytotoxicity	Neurotrophin signaling pathway	PI3K-Akt signaling pathway
T cell receptor signaling pathway

Motif

Protein

Start

End

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Information

Evidence

ErbB signaling pathway (KEGG - hsa04012)
LIG_SH2_GRB2	ERBB3_HUMAN	1262	1265	Binary	Physicochemical compatibility	Phosphorylation of Y1262 in the SH2-binding motif of Receptor tyrosine-protein kinase erbB-3 (ERBB3) induces binding to Growth factor receptor-bound protein 2 (GRB2).	details	Curated
Fc epsilon RI signaling pathway (KEGG - mmu04664)
LIG_SH2_GRB2	LAT_MOUSE	175	178	Binary	Physicochemical compatibility	Phosphorylation of Y175 in the SH2-binding motif of Linker for activation of T-cells family member 1 (Lat) induces binding to the Growth factor receptor-bound protein 2 (Grb2) protein.	details	Inferred
LIG_SH2_GRB2	LAT_MOUSE	195	198	Binary	Physicochemical compatibility	Phosphorylation of Y195 in the SH2-binding motif of Linker for activation of T-cells family member 1 (Lat) induces binding to the Growth factor receptor-bound protein 2 (Grb2) protein.	details	Inferred
LIG_SH2_GRB2	LAT_MOUSE	235	238	Binary	Physicochemical compatibility	Phosphorylation of Y235 in the SH2-binding motif of Linker for activation of T-cells family member 1 (Lat) induces binding to the Growth factor receptor-bound protein 2 (Grb2) protein.	details	Inferred
Insulin signaling pathway (KEGG - rno04910)
LIG_SH2_GRB2	IRS1_RAT	895	898	Binary	Physicochemical compatibility	Phosphorylation of Y895 in the SH2-binding motif of Insulin receptor substrate 1 (Irs1) induces binding to the Growth factor receptor-bound protein 2 (Grb2) protein.	details	Inferred
Natural killer cell mediated cytotoxicity (KEGG - mmu04650)
LIG_SH2_GRB2	LAT_MOUSE	175	178	Binary	Physicochemical compatibility	Phosphorylation of Y175 in the SH2-binding motif of Linker for activation of T-cells family member 1 (Lat) induces binding to the Growth factor receptor-bound protein 2 (Grb2) protein.	details	Inferred
LIG_SH2_GRB2	LAT_MOUSE	195	198	Binary	Physicochemical compatibility	Phosphorylation of Y195 in the SH2-binding motif of Linker for activation of T-cells family member 1 (Lat) induces binding to the Growth factor receptor-bound protein 2 (Grb2) protein.	details	Inferred
LIG_SH2_GRB2	LAT_MOUSE	235	238	Binary	Physicochemical compatibility	Phosphorylation of Y235 in the SH2-binding motif of Linker for activation of T-cells family member 1 (Lat) induces binding to the Growth factor receptor-bound protein 2 (Grb2) protein.	details	Inferred
Neurotrophin signaling pathway (KEGG - rno04722)
LIG_SH2_GRB2	IRS1_RAT	895	898	Binary	Physicochemical compatibility	Phosphorylation of Y895 in the SH2-binding motif of Insulin receptor substrate 1 (Irs1) induces binding to the Growth factor receptor-bound protein 2 (Grb2) protein.	details	Inferred
PI3K-Akt signaling pathway (KEGG - rno04151)
LIG_SH2_GRB2	IRS1_RAT	895	898	Binary	Physicochemical compatibility	Phosphorylation of Y895 in the SH2-binding motif of Insulin receptor substrate 1 (Irs1) induces binding to the Growth factor receptor-bound protein 2 (Grb2) protein.	details	Inferred
T cell receptor signaling pathway (KEGG - mmu04660)
LIG_SH2_GRB2	LAT_MOUSE	175	178	Binary	Physicochemical compatibility	Phosphorylation of Y175 in the SH2-binding motif of Linker for activation of T-cells family member 1 (Lat) induces binding to the Growth factor receptor-bound protein 2 (Grb2) protein.	details	Inferred
LIG_SH2_GRB2	LAT_MOUSE	195	198	Binary	Physicochemical compatibility	Phosphorylation of Y195 in the SH2-binding motif of Linker for activation of T-cells family member 1 (Lat) induces binding to the Growth factor receptor-bound protein 2 (Grb2) protein.	details	Inferred
LIG_SH2_GRB2	LAT_MOUSE	235	238	Binary	Physicochemical compatibility	Phosphorylation of Y235 in the SH2-binding motif of Linker for activation of T-cells family member 1 (Lat) induces binding to the Growth factor receptor-bound protein 2 (Grb2) protein.	details	Inferred