switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: ELM:LIG_SH2_GRB2 (15 hits) x

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Curated inferred

x Index

Cyclin-dependent kinase 1	Glycogen synthase kinase-3 beta	Insulin receptor
Insulin receptor (Rattus)	Insulin-like growth factor 1 receptor	Tyrosine-protein kinase Fyn
Tyrosine-protein kinase Fyn (Mus)	Tyrosine-protein kinase ZAP-70	Tyrosine-protein kinase ZAP-70 (Mus)

Motif

Protein

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Information

Evidence

Cyclin-dependent kinase 1 - CDK1 - Homo sapiens
LIG_SH2_GRB2	A4_HUMAN	757	760	Cumulative	Rheostatic	While phosphorylation of Y757 in the SH2-binding motif of Amyloid beta A4 protein (APP) induces binding to Growth factor receptor-bound protein 2 (GRB2), additional phosphorylation of T743 further increases the strength of the interaction.	details	Inferred
Glycogen synthase kinase-3 beta - GSK3B - Homo sapiens
LIG_SH2_GRB2	A4_HUMAN	757	760	Cumulative	Rheostatic	While phosphorylation of Y757 in the SH2-binding motif of Amyloid beta A4 protein (APP) induces binding to Growth factor receptor-bound protein 2 (GRB2), additional phosphorylation of T743 further increases the strength of the interaction.	details	Inferred
Insulin receptor - INSR - Homo sapiens
LIG_SH2_GRB2	IRS1_RAT	895	898	Binary	Physicochemical compatibility	Phosphorylation of Y895 in the SH2-binding motif of Insulin receptor substrate 1 (Irs1) induces binding to the Growth factor receptor-bound protein 2 (Grb2) protein.	details	Inferred
LIG_SH2_GRB2	IRS1_RAT	895	898	Binary	Physicochemical compatibility	Phosphorylation of Y895 in the SH2-binding motif of Insulin receptor substrate 1 (Irs1) induces binding to the Growth factor receptor-bound protein 2 (Grb2) protein.	details	Inferred
Insulin receptor - INSR - Rattus norvegicus
LIG_SH2_GRB2	IRS1_RAT	895	898	Binary	Physicochemical compatibility	Phosphorylation of Y895 in the SH2-binding motif of Insulin receptor substrate 1 (Irs1) induces binding to the Growth factor receptor-bound protein 2 (Grb2) protein.	details	Inferred
Insulin-like growth factor 1 receptor - IGF1R - Homo sapiens
LIG_SH2_GRB2	IRS1_RAT	895	898	Binary	Physicochemical compatibility	Phosphorylation of Y895 in the SH2-binding motif of Insulin receptor substrate 1 (Irs1) induces binding to the Growth factor receptor-bound protein 2 (Grb2) protein.	details	Inferred
Tyrosine-protein kinase Fyn - FYN - Homo sapiens
LIG_SH2_GRB2	A4_HUMAN	757	760	Cumulative	Rheostatic	While phosphorylation of Y757 in the SH2-binding motif of Amyloid beta A4 protein (APP) induces binding to Growth factor receptor-bound protein 2 (GRB2), additional phosphorylation of T743 further increases the strength of the interaction.	details	Inferred
LIG_SH2_GRB2	A4_HUMAN	757	760	Specificity	Altered binding specificity	Phosphorylation of Y757 in APP (Amyloid beta A4 protein (APP)) switches its specificity from PTB domain containing proteins, like Amyloid beta A4 precursor protein-binding family B member 1 (APBB1), which is involved in trafficking and processing of APP, to SH2 domain containing proteins, such as Growth factor receptor-bound protein 2 (GRB2).	details	Inferred
Tyrosine-protein kinase Fyn - FYN - Mus musculus
LIG_SH2_GRB2	IRS1_RAT	895	898	Binary	Physicochemical compatibility	Phosphorylation of Y895 in the SH2-binding motif of Insulin receptor substrate 1 (Irs1) induces binding to the Growth factor receptor-bound protein 2 (Grb2) protein.	details	Inferred
Tyrosine-protein kinase ZAP-70 - ZAP70 - Homo sapiens
LIG_SH2_GRB2	LAT_MOUSE	175	178	Binary	Physicochemical compatibility	Phosphorylation of Y175 in the SH2-binding motif of Linker for activation of T-cells family member 1 (Lat) induces binding to the Growth factor receptor-bound protein 2 (Grb2) protein.	details	Inferred
LIG_SH2_GRB2	LAT_MOUSE	195	198	Binary	Physicochemical compatibility	Phosphorylation of Y195 in the SH2-binding motif of Linker for activation of T-cells family member 1 (Lat) induces binding to the Growth factor receptor-bound protein 2 (Grb2) protein.	details	Inferred
LIG_SH2_GRB2	LAT_MOUSE	235	238	Binary	Physicochemical compatibility	Phosphorylation of Y235 in the SH2-binding motif of Linker for activation of T-cells family member 1 (Lat) induces binding to the Growth factor receptor-bound protein 2 (Grb2) protein.	details	Inferred
Tyrosine-protein kinase ZAP-70 - ZAP70 - Mus musculus
LIG_SH2_GRB2	LAT_MOUSE	175	178	Binary	Physicochemical compatibility	Phosphorylation of Y175 in the SH2-binding motif of Linker for activation of T-cells family member 1 (Lat) induces binding to the Growth factor receptor-bound protein 2 (Grb2) protein.	details	Inferred
LIG_SH2_GRB2	LAT_MOUSE	195	198	Binary	Physicochemical compatibility	Phosphorylation of Y195 in the SH2-binding motif of Linker for activation of T-cells family member 1 (Lat) induces binding to the Growth factor receptor-bound protein 2 (Grb2) protein.	details	Inferred
LIG_SH2_GRB2	LAT_MOUSE	235	238	Binary	Physicochemical compatibility	Phosphorylation of Y235 in the SH2-binding motif of Linker for activation of T-cells family member 1 (Lat) induces binding to the Growth factor receptor-bound protein 2 (Grb2) protein.	details	Inferred