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Group by :Switch typeMotif classProteinEnzymePathway            Group Index    Colouring Info              Filtered: ELM:LIG_SH2_GRB2 (7 hits) x
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  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
  Uncategorised  Rheostatic  Allostery  Avidity-sensing
  Physicochemical compatibility  Pre-translational  Competition

x  Index
Amyloid beta A4 proteinInsulin receptor substrate 1 (Rattus)Linker for activation of T-cells family member 1 (Mus)
Receptor tyrosine-protein kinase erbB-3


MotifStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

Amyloid beta A4 protein - APP -  Homo sapiens
LIG_SH2_GRB2757760CumulativeRheostaticWhile phosphorylation of Y757 in the SH2-binding motif of Amyloid beta A4 protein (APP) induces binding to Growth factor receptor-bound protein 2 (GRB2), additional phosphorylation of T743 further increases the strength of the interaction.
details
LIG_SH2_GRB2757760SpecificityAltered binding specificityPhosphorylation of Y757 in APP (Amyloid beta A4 protein (APP)) switches its specificity from PTB domain containing proteins, like Amyloid beta A4 precursor protein-binding family B member 1 (APBB1), which is involved in trafficking and processing of APP, to SH2 domain containing proteins, such as Growth factor receptor-bound protein 2 (GRB2).
details

Insulin receptor substrate 1 - Irs1 -  Rattus norvegicus
LIG_SH2_GRB2895898BinaryPhysicochemical compatibilityPhosphorylation of Y895 in the SH2-binding motif of Insulin receptor substrate 1 (Irs1) induces binding to the Growth factor receptor-bound protein 2 (Grb2) protein.
details

Linker for activation of T-cells family member 1 - Lat -  Mus musculus
LIG_SH2_GRB2175178BinaryPhysicochemical compatibilityPhosphorylation of Y175 in the SH2-binding motif of Linker for activation of T-cells family member 1 (Lat) induces binding to the Growth factor receptor-bound protein 2 (Grb2) protein.
details
LIG_SH2_GRB2195198BinaryPhysicochemical compatibilityPhosphorylation of Y195 in the SH2-binding motif of Linker for activation of T-cells family member 1 (Lat) induces binding to the Growth factor receptor-bound protein 2 (Grb2) protein.
details
LIG_SH2_GRB2235238BinaryPhysicochemical compatibilityPhosphorylation of Y235 in the SH2-binding motif of Linker for activation of T-cells family member 1 (Lat) induces binding to the Growth factor receptor-bound protein 2 (Grb2) protein.
details

Receptor tyrosine-protein kinase erbB-3 - ERBB3 -  Homo sapiens
LIG_SH2_GRB212621265BinaryPhysicochemical compatibilityPhosphorylation of Y1262 in the SH2-binding motif of Receptor tyrosine-protein kinase erbB-3 (ERBB3) induces binding to Growth factor receptor-bound protein 2 (GRB2).
details
           
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