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Filtered:
ELM:LIG_SH2_IB (12 hits)
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Index
Chemokine signaling pathway
ErbB signaling pathway
Focal adhesion
Insulin signaling pathway
Neurotrophin signaling pathway
Regulation of actin cytoskeleton
Motif
Protein
Start
End
Switch Type
Switch Subtype
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Information
Evidence
Chemokine signaling pathway
(
KEGG - hsa04062
)
LIG_SH2_IB
BCAR1_HUMAN
358
368
Binary
Physicochemical compatibility
Phosphorylation of Y362 in the SH2-binding motif of
Breast cancer anti-estrogen resistance protein 1 (BCAR1)
induces binding to the
Adapter molecule crk (CRK)
protein.
details
Inferred
LIG_SH2_IB
PAXI_HUMAN
118
121
Binary
Pre‑translational
Alternative splicing removes the SH2-binding motif of
Paxillin (PXN)
, abrogating binding to
Adapter molecule crk (CRK)
.
details
Inferred
LIG_SH2_IB
PAXI_HUMAN
31
34
Binary
Pre‑translational
Alternative splicing removes the SH2-binding motif of
Paxillin (PXN)
, abrogating binding to
Adapter molecule crk (CRK)
.
details
Inferred
ErbB signaling pathway
(
KEGG - hsa04012
)
LIG_SH2_IB
CBL_HUMAN
770
780
Binary
Physicochemical compatibility
Phosphorylation of Y774 in the SH2-binding motif of
E3 ubiquitin-protein ligase CBL (CBL)
induces binding to the
Adapter molecule crk (CRK)
protein.
details
Inferred
Focal adhesion
(
KEGG - hsa04510
)
LIG_SH2_IB
BCAR1_HUMAN
358
368
Binary
Physicochemical compatibility
Phosphorylation of Y362 in the SH2-binding motif of
Breast cancer anti-estrogen resistance protein 1 (BCAR1)
induces binding to the
Adapter molecule crk (CRK)
protein.
details
Inferred
LIG_SH2_IB
PAXI_HUMAN
118
121
Binary
Pre‑translational
Alternative splicing removes the SH2-binding motif of
Paxillin (PXN)
, abrogating binding to
Adapter molecule crk (CRK)
.
details
Inferred
LIG_SH2_IB
PAXI_HUMAN
31
34
Binary
Pre‑translational
Alternative splicing removes the SH2-binding motif of
Paxillin (PXN)
, abrogating binding to
Adapter molecule crk (CRK)
.
details
Inferred
Insulin signaling pathway
(
KEGG - hsa04910
)
LIG_SH2_IB
CBL_HUMAN
770
780
Binary
Physicochemical compatibility
Phosphorylation of Y774 in the SH2-binding motif of
E3 ubiquitin-protein ligase CBL (CBL)
induces binding to the
Adapter molecule crk (CRK)
protein.
details
Inferred
Neurotrophin signaling pathway
(
KEGG - hsa04722
)
LIG_SH2_IB
NTRK1_HUMAN
783
796
Binary
Physicochemical compatibility
Phosphorylation of Y791 in the SH2-binding motif of
High affinity nerve growth factor receptor (NTRK1)
induces binding to the
Megakaryocyte-associated tyrosine-protein kinase (MATK)
protein.
details
Inferred
Regulation of actin cytoskeleton
(
KEGG - hsa04810
)
LIG_SH2_IB
BCAR1_HUMAN
358
368
Binary
Physicochemical compatibility
Phosphorylation of Y362 in the SH2-binding motif of
Breast cancer anti-estrogen resistance protein 1 (BCAR1)
induces binding to the
Adapter molecule crk (CRK)
protein.
details
Inferred
LIG_SH2_IB
PAXI_HUMAN
118
121
Binary
Pre‑translational
Alternative splicing removes the SH2-binding motif of
Paxillin (PXN)
, abrogating binding to
Adapter molecule crk (CRK)
.
details
Inferred
LIG_SH2_IB
PAXI_HUMAN
31
34
Binary
Pre‑translational
Alternative splicing removes the SH2-binding motif of
Paxillin (PXN)
, abrogating binding to
Adapter molecule crk (CRK)
.
details
Inferred