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| Domain hiding | Altered binding specificity | Motif hiding | Composite binding site formation |
| Uncategorised | Rheostatic | Allostery | Avidity-sensing |
| Physicochemical compatibility | Pre-translational | Competition |
| Motif | Start | End | Switch Type | Switch Subtype | Switch Description | Information |
Breast cancer anti-estrogen resistance protein 1 - BCAR1 - Homo sapiens | |||||||
| LIG_SH2_IB | 358 | 368 | Binary | Physicochemical compatibility | Phosphorylation of Y362 in the SH2-binding motif of Breast cancer anti-estrogen resistance protein 1 (BCAR1) induces binding to the Adapter molecule crk (CRK) protein. | ||
Disabled homolog 1 - DAB1 - Homo sapiens | |||||||
| LIG_SH2_IB | 211 | 230 | Binary | Physicochemical compatibility | Phosphorylation of Y220 in the SH2-binding motif of Disabled homolog 1 (DAB1) induces binding to the Adapter molecule crk (CRK) protein. | ||
Docking protein 1 - DOK1 - Homo sapiens | |||||||
| LIG_SH2_IB | 447 | 454 | Binary | Physicochemical compatibility | Phosphorylation of Y449 in the SH2-binding motif of Docking protein 1 (DOK1) induces binding to the SH2 domain-containing protein 1A (SH2D1A) protein. | ||
E3 ubiquitin-protein ligase CBL - CBL - Homo sapiens | |||||||
| LIG_SH2_IB | 770 | 780 | Binary | Physicochemical compatibility | Phosphorylation of Y774 in the SH2-binding motif of E3 ubiquitin-protein ligase CBL (CBL) induces binding to the Adapter molecule crk (CRK) protein. | ||
Ephrin type-B receptor 2 - Ephb2 - Mus musculus | |||||||
| LIG_SH2_IB | 601 | 610 | Binary | Physicochemical compatibility | Phosphorylation of Y604 in the SH2-binding motif of Ephrin type-B receptor 2 (Ephb2) induces binding to the Adapter molecule crk (CRK) protein. | ||
| LIG_SH2_IB | 606 | 620 | Binary | Physicochemical compatibility | Phosphorylation of Y610 in the SH2-binding motif of Ephrin type-B receptor 2 (Ephb2) induces binding to the Adapter molecule crk (CRK) protein. | ||
High affinity nerve growth factor receptor - NTRK1 - Homo sapiens | |||||||
| LIG_SH2_IB | 783 | 796 | Binary | Physicochemical compatibility | Phosphorylation of Y791 in the SH2-binding motif of High affinity nerve growth factor receptor (NTRK1) induces binding to the Megakaryocyte-associated tyrosine-protein kinase (MATK) protein. | ||
Paxillin - PXN - Homo sapiens | |||||||
| LIG_SH2_IB | 118 | 121 | Binary | Pre‑translational | Alternative splicing removes the SH2-binding motif of Paxillin (PXN), abrogating binding to Ras GTPase-activating protein 1 (RASA1). | ||
| LIG_SH2_IB | 118 | 121 | Binary | Pre‑translational | Alternative splicing removes the SH2-binding motif of Paxillin (PXN), abrogating binding to Adapter molecule crk (CRK). | ||
| LIG_SH2_IB | 31 | 34 | Binary | Pre‑translational | Alternative splicing removes the SH2-binding motif of Paxillin (PXN), abrogating binding to Adapter molecule crk (CRK). | ||
| LIG_SH2_IB | 118 | 121 | Binary | Pre‑translational | Alternative splicing removes the SH2-binding motif of Paxillin (PXN), abrogating binding to Ras GTPase-activating protein 1 (RASA1). | ||
Protein-tyrosine kinase 2-beta - PTK2B - Homo sapiens | |||||||
| LIG_SH2_IB | 394 | 410 | Binary | Physicochemical compatibility | Phosphorylation of Y402 in the SH2-binding motif of Protein-tyrosine kinase 2-beta (PTK2B) induces binding to the Megakaryocyte-associated tyrosine-protein kinase (MATK) protein. | ||
Signaling lymphocytic activation molecule - SLAMF1 - Homo sapiens | |||||||
| LIG_SH2_IB | 276 | 286 | Binary | Physicochemical compatibility | Phosphorylation of Y281 in the SH2-binding motif of Signaling lymphocytic activation molecule (SLAMF1) induces binding to the SH2 domain-containing protein 1A (SH2D1A) protein. | ||
| LIG_SH2_IB | 273 | 286 | Binary | Physicochemical compatibility | Phosphorylation of Y281 in the SH2-binding motif of Signaling lymphocytic activation molecule (SLAMF1) induces binding to the SH2 domain-containing protein 1B (Sh2d1b) protein. | ||