switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:P46108 (12 hits) x

x Coloured by: Pathway evidence source
Curated inferred

x Index

Chemokine signaling pathway	ErbB signaling pathway	Focal adhesion
Insulin signaling pathway	Regulation of actin cytoskeleton

Motif

Protein

Start

End

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Information

Evidence

Chemokine signaling pathway (KEGG - hsa04062)
LIG_SH2_IB	BCAR1_HUMAN	358	368	Binary	Physicochemical compatibility	Phosphorylation of Y362 in the SH2-binding motif of Breast cancer anti-estrogen resistance protein 1 (BCAR1) induces binding to the Adapter molecule crk (CRK) protein.	details	Inferred
LIG_SH2_IB	PAXI_HUMAN	118	121	Binary	Pre‑translational	Alternative splicing removes the SH2-binding motif of Paxillin (PXN), abrogating binding to Adapter molecule crk (CRK).	details	Inferred
LIG_SH2_IB	PAXI_HUMAN	31	34	Binary	Pre‑translational	Alternative splicing removes the SH2-binding motif of Paxillin (PXN), abrogating binding to Adapter molecule crk (CRK).	details	Inferred
ErbB signaling pathway (KEGG - hsa04012)
LIG_SH2_IB	CBL_HUMAN	770	780	Binary	Physicochemical compatibility	Phosphorylation of Y774 in the SH2-binding motif of E3 ubiquitin-protein ligase CBL (CBL) induces binding to the Adapter molecule crk (CRK) protein.	details	Inferred
LIG_SH2_SRC	EGFR_HUMAN	1125	1128	Binary	Physicochemical compatibility	Phosphorylation of Y1125 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to Adapter molecule crk (CRK).	details	Curated
Focal adhesion (KEGG - hsa04510)
LIG_SH2_IB	BCAR1_HUMAN	358	368	Binary	Physicochemical compatibility	Phosphorylation of Y362 in the SH2-binding motif of Breast cancer anti-estrogen resistance protein 1 (BCAR1) induces binding to the Adapter molecule crk (CRK) protein.	details	Inferred
LIG_SH2_IB	PAXI_HUMAN	118	121	Binary	Pre‑translational	Alternative splicing removes the SH2-binding motif of Paxillin (PXN), abrogating binding to Adapter molecule crk (CRK).	details	Inferred
LIG_SH2_IB	PAXI_HUMAN	31	34	Binary	Pre‑translational	Alternative splicing removes the SH2-binding motif of Paxillin (PXN), abrogating binding to Adapter molecule crk (CRK).	details	Inferred
Insulin signaling pathway (KEGG - hsa04910)
LIG_SH2_IB	CBL_HUMAN	770	780	Binary	Physicochemical compatibility	Phosphorylation of Y774 in the SH2-binding motif of E3 ubiquitin-protein ligase CBL (CBL) induces binding to the Adapter molecule crk (CRK) protein.	details	Inferred
Regulation of actin cytoskeleton (KEGG - hsa04810)
LIG_SH2_IB	BCAR1_HUMAN	358	368	Binary	Physicochemical compatibility	Phosphorylation of Y362 in the SH2-binding motif of Breast cancer anti-estrogen resistance protein 1 (BCAR1) induces binding to the Adapter molecule crk (CRK) protein.	details	Inferred
LIG_SH2_IB	PAXI_HUMAN	118	121	Binary	Pre‑translational	Alternative splicing removes the SH2-binding motif of Paxillin (PXN), abrogating binding to Adapter molecule crk (CRK).	details	Inferred
LIG_SH2_IB	PAXI_HUMAN	31	34	Binary	Pre‑translational	Alternative splicing removes the SH2-binding motif of Paxillin (PXN), abrogating binding to Adapter molecule crk (CRK).	details	Inferred