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| Domain hiding | Altered binding specificity | Motif hiding | Composite binding site formation |
| Uncategorised | Rheostatic | Allostery | Avidity-sensing |
| Physicochemical compatibility | Pre-translational | Competition |
| Motif | Start | End | Switch Type | Switch Subtype | Switch Description | Information |
Disintegrin albolabrin - - Cryptelytrops albolabris | |||||||
| LIG_RGD | 51 | 53 | Pre‑assembly | Composite binding site formation | Binding of Disintegrin albolabrin to integrin receptors depends on pre-assembly of Integrin alpha-IIb (ITGA2B)-Integrin beta-3 (ITGB3) heterodimers, since association of the integrin alpha and beta subunits results in the formation of a composite binding site for the RGD motif in the ligand. | ||
Disintegrin trigramin-beta-2 - - Trimeresurus gramineus | |||||||
| LIG_RGD | 51 | 53 | Pre‑assembly | Composite binding site formation | Binding of Disintegrin trigramin-beta-2 to integrin receptors depends on pre-assembly of Integrin alpha-IIb (ITGA2B)-Integrin beta-3 (ITGB3) heterodimers, since association of the integrin alpha and beta subunits results in the formation of a composite binding site for the RGD motif in the ligand. | ||
EGF-like repeat and discoidin I-like domain-containing protein 3 - EDIL3 - Homo sapiens | |||||||
| LIG_RGD | 96 | 98 | Pre‑assembly | Composite binding site formation | Binding of EGF-like repeat and discoidin I-like domain-containing protein 3 (EDIL3) to integrin receptors depends on pre-assembly of Integrin alpha-V (ITGAV)-Integrin beta-3 (ITGB3) heterodimers, since association of the integrin alpha and beta subunits results in the formation of a composite binding site for the RGD motif in the ligand. | ||
Fibronectin - FN1 - Homo sapiens | |||||||
| LIG_RGD | 1524 | 1526 | Pre‑assembly | Composite binding site formation | Binding of Fibronectin (FN1) to integrin receptors depends on pre-assembly of Integrin alpha-V (ITGAV)-Integrin beta-3 (ITGB3) heterodimers, since association of the integrin alpha and beta subunits results in the formation of a composite binding site for the RGD motif in the ligand. | ||
Fibronectin - Fn1 - Mus musculus | |||||||
| LIG_RGD | 1614 | 1616 | Pre‑assembly | Composite binding site formation | Binding of Fibronectin (Fn1) to integrin receptors depends on pre-assembly of Integrin alpha-5 (Itga5)-Integrin beta-1 (Itgb1) heterodimers, since association of the integrin alpha and beta subunits results in the formation of a composite binding site for the RGD motif in the ligand. | ||
Genome polyprotein - - Foot-and-mouth disease virus (strain O1) | |||||||
| LIG_RGD | 869 | 871 | Pre‑assembly | Composite binding site formation | Binding of Genome polyprotein to integrin receptors depends on pre-assembly of Integrin alpha-V (ITGAV)-Integrin beta-3 (ITGB3) heterodimers, since association of the integrin alpha and beta subunits results in the formation of a composite binding site for the RGD motif in the ligand. | ||
Genome polyprotein - - Coxsackievirus A9 (strain Griggs) | |||||||
| LIG_RGD | 858 | 860 | Pre‑assembly | Composite binding site formation | Binding of Genome polyprotein to integrin receptors depends on pre-assembly of Integrin alpha-V (ITGAV)-Integrin beta-6 (ITGB6) heterodimers, since association of the integrin alpha and beta subunits results in the formation of a composite binding site for the RGD motif in the ligand. | ||
Genome polyprotein - - Human parechovirus 1 (strain Harris) | |||||||
| LIG_RGD | 764 | 766 | Pre‑assembly | Composite binding site formation | Binding of Genome polyprotein to integrin receptors depends on pre-assembly of Integrin alpha-V (ITGAV)-Integrin beta-6 (ITGB6) heterodimers, since association of the integrin alpha and beta subunits results in the formation of a composite binding site for the RGD motif in the ligand. | ||
Osteopontin - SPP1 - Homo sapiens | |||||||
| LIG_RGD | 159 | 161 | Pre‑assembly | Composite binding site formation | Binding of EGF-like repeat and discoidin I-like domain-containing protein 3 (EDIL3) to integrin receptors depends on pre-assembly of Integrin alpha-V (ITGAV)-Integrin beta-3 (ITGB3) heterodimers, since association of the integrin alpha and beta subunits results in the formation of a composite binding site for the RGD motif in the ligand. | ||
Vitronectin - VTN - Homo sapiens | |||||||
| LIG_RGD | 64 | 66 | Pre‑assembly | Composite binding site formation | Binding of Vitronectin (VTN) to integrin receptors depends on pre-assembly of Integrin alpha-V (ITGAV)-Integrin beta-3 (ITGB3) heterodimers, since association of the integrin alpha and beta subunits results in the formation of a composite binding site for the RGD motif in the ligand. | ||
Vitronectin - Vtn - Mus musculus | |||||||
| LIG_RGD | 64 | 66 | Pre‑assembly | Composite binding site formation | Binding of Vitronectin (Vtn) to integrin receptors depends on pre-assembly of Integrin alpha-V (Itgav)-Integrin beta-3 (Itgb3) heterodimers, since association of the integrin alpha and beta subunits results in the formation of a composite binding site for the RGD motif in the ligand. | ||
Zinc metalloproteinase/disintegrin - - Protobothrops elegans | |||||||
| LIG_RGD | 459 | 461 | Pre‑assembly | Composite binding site formation | Binding of Zinc metalloproteinase/disintegrin to integrin receptors depends on pre-assembly of Integrin alpha-IIb (ITGA2B)-Integrin beta-3 (ITGB3) heterodimers, since association of the integrin alpha and beta subunits results in the formation of a composite binding site for the RGD motif in the ligand. | ||
von Willebrand factor - VWF - Homo sapiens | |||||||
| LIG_RGD | 2507 | 2509 | Pre‑assembly | Composite binding site formation | Binding of von Willebrand factor (VWF) to integrin receptors depends on pre-assembly of Integrin alpha-V (ITGAV)-Integrin beta-3 (ITGB3) heterodimers, since association of the integrin alpha and beta subunits results in the formation of a composite binding site for the RGD motif in the ligand. | ||