About Help Definitions Submit Search Analyse Browse Home


Group by :Switch typeMotif classProteinEnzymePathway            Group Index    Colouring Info              Filtered: ELM:LIG_SH3_3 (6 hits) x
submit


x  Coloured by switch type.
  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
  Uncategorised  Rheostatic  Allostery  Avidity-sensing
  Physicochemical compatibility  Pre-translational  Competition

x  Index
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1DystroglycanMicrotubule-associated protein tau
Myc box-dependent-interacting protein 1T-cell surface antigen CD2


MotifStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 - PLCB1 -  Homo sapiens
LIG_SH3_311621168BinaryPre‑translationalAlternative splicing removes the SH3-binding motif of Isoform B of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1), abrogating binding to SH3 and multiple ankyrin repeat domains protein 3 (SHANK3). PLCB1 associates with a SHANK3 complex in cardiomyocytes via its splice variant-specific C-terminal tail. Studies show that Isoform B of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1) selectively mediates downstream responses initiated by Gq-coupled receptors, in particular hypertrophy and apoptosis.
details

Dystroglycan - DAG1 -  Homo sapiens
LIG_SH3_3888894SpecificityCompetitionThe WW-binding motif for Dystrophin (DMD) and the SH3-binding motif for Growth factor receptor-bound protein 2 (GRB2) on Dystroglycan (DAG1) overlap, making their interactions mutually exclusive and competitive.
details
LIG_SH3_3888894SpecificityCompetitionThe WW-binding motif for Dystrophin (DMD) and the SH3-binding motif for Growth factor receptor-bound protein 2 (GRB2) on Dystroglycan (DAG1) overlap, making their interactions mutually exclusive and competitive.
details

Microtubule-associated protein tau - MAPT -  Homo sapiens
LIG_SH3_3213219BinaryPhysicochemical compatibilityPhosphorylation of S210 adjacent to the SH3-binding motif of Isoform Tau-F of Microtubule-associated protein tau (MAPT) inhibits binding to Tyrosine-protein kinase Fyn (Fyn).
details

Myc box-dependent-interacting protein 1 - BIN1 -  Homo sapiens
LIG_SH3_3305311SpecificityDomain hidingAn intramolecular interaction of an SH3 binding motif, encoded by exon 12A, in Isoform II2 of Myc box-dependent-interacting protein 1 (BIN1) with the SH3 domain of Bin1 prevents interaction of the Bin1 SH3 domain with the SH3 binding motif of Isoform II2 of Myc box-dependent-interacting protein 1 (BIN1).
details

T-cell surface antigen CD2 - CD2 -  Homo sapiens
LIG_SH3_3294300SpecificityCompetitionT-cell surface antigen CD2 (CD2) uses overlapping motifs to bind to CD2 antigen cytoplasmic tail-binding protein 2 (CD2BP2) and Fyn, which makes their interactions mutually exclusive. Since CD2BP2 and Tyrosine-protein kinase Fyn (FYN) reside in different subcellular locations, the specificity of CD2 for the two competitors is switched by changing its cellular localization, from non-raft membranes to lipid raft membranes.
details
           
Please send any suggestions/comments to: switches@elm.eu.org