About Help Definitions Submit Search Analyse Browse Home


Group by :Switch typeMotif classProteinEnzymePathway            Group Index    Colouring Info              Filtered: UNIPROT:O94826 (8 hits) x


x  Coloured by switch type.
  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
  Uncategorised  Rheostatic  Allostery  Avidity-sensing
  Physicochemical compatibility  Pre-translational  Competition

x  Index
TRG_MLS


ProteinStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

TRG_MLS -
CACP_HUMAN121BinaryPre‑translationalAlternative splicing removes the mitochondrial localisation signal (MLS) motif of Carnitine O-acetyltransferase (CRAT), abrogating binding to Mitochondrial import receptor subunit TOM70 (TOMM70A). As a result, Isoform SM-1200 of Carnitine O-acetyltransferase (CRAT), which lacks the MLS, is located in peroxisomes due to a PTS1 motif in its C-terminus.
details
DBLOH_HUMAN155BinaryPre‑translationalAlternative splicing removes the BIR-binding motif of Diablo homolog, mitochondrial (DIABLO), abrogating binding to Mitochondrial import receptor subunit TOM70 (TOMM70A). Isoform SMAC3 of Diablo homolog, mitochondrial (DIABLO) is localised to mitochondria via its mitochondrial localisation signal (MLS). Upon entry in mitochondria the MLS is cleaved and Isoform SMAC3 of Diablo homolog, mitochondrial (DIABLO) is found localised with cytochrome-c. During apoptosis, Isoform SMAC3 of Diablo homolog, mitochondrial (DIABLO) binds to the second/third BIR domain of Baculoviral IAP repeat-containing protein 4 (XIAP). This interaction disrupts binding of XIAP to processed Caspase-9 (CASP9) and promotes Caspase-3 (CASP3) activation. Isoform SMAC3 of Diablo homolog, mitochondrial (DIABLO) also promotes ubiquitination of XIAP and subsequent degradation. Isoform 1 of Diablo homolog, mitochondrial (DIABLO) on the other hand did not cause degradation of XIAP.
details
UNG_HUMAN144BinaryPre‑translationalAlternative promoter usage removes the mitochondrial localisation signal (MLS) of Isoform UNG1 of Uracil-DNA glycosylase (UNG), abrogating binding to Mitochondrial import receptor subunit TOM70 (TOMM70A) and import into mitochondria. In Isoform UNG2 of Uracil-DNA glycosylase (UNG) the MLS present in Isoform UNG1 of Uracil-DNA glycosylase (UNG) is replaced with a nuclear localisation signal (NLS), promoting different localisations of the different protein isoforms.
details
TRM1_YEAST116BinaryPre‑translationalAlternative initiation removes the mitochondrial localisation signal (MLS) motif of tRNA (guanine(26)-N(2))-dimethyltransferase, mitochondrial (TRM1), abrogating binding to Mitochondrial import receptor subunit TOM70 (TOMM70A). Both variants contain a weak nuclear localisation signal (NLS) (KKSKKKRC). However, this motif is over-powered by the MLS and therefore the full-length variant is localised to mitochondria. Alternative initiation removes the N-terminus and the MLS motif, resulting in a nuclear localisation for the truncated isoform.
details
MOD5_MOUSE147BinaryPre‑translationalAlternative splicing removes the mitochondrial localisation signal (MLS) motif of tRNA dimethylallyltransferase, mitochondrial (Trit1), abrogating binding to Mitochondrial import receptor subunit TOM70 (TOMM70A). The IPPT-I isoform (also known as Isoform 1 of tRNA dimethylallyltransferase, mitochondrial (Trit1)) was found to localise to both the mitochondria and the cytosol whereas the IPPT-II isoform (also known as Isoform 2 of tRNA dimethylallyltransferase, mitochondrial (Trit1)) is only localised to the cytosol and the nucleus. No nuclear localisation signal (NLS) was identified in either splice variant.
details
SYK_HUMAN149BinaryPre‑translationalAlternative splicing removes the mitochondrial localisation signal (MLS) motif of Isoform Mitochondrial of Lysine--tRNA ligase (KARS), abrogating binding to Mitochondrial import receptor subunit TOM70 (TOMM70A) and import into mitochondria. Unusually, the first two exons of Lysine--tRNA ligase (KARS) are non-constitutive. The first exon does not contain a localisation signal (resulting in cytosol localisation) whereas the second exon contains an MLS.
details
GLRX2_HUMAN121BinaryPre‑translationalAlternative splicing removes the mitochondrial localisation signal (MLS) motif of Glutaredoxin-2, mitochondrial (GLRX2), abrogating binding to Mitochondrial import receptor subunit TOM70 (TOMM70A) and import into mitochondria. The Grx2a isoform Isoform Grx2a of Glutaredoxin-2, mitochondrial (GLRX2) is localised to the mitochondria whereas the Isoform Grx2b of Glutaredoxin-2, mitochondrial (GLRX2) is localised to the perinuclear region.
details
DUT_HUMAN169BinaryPre‑translationalAlternative splicing removes the mitochondrial localisation signal (MLS) motif of Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (DUT), abrogating binding to Mitochondrial import receptor subunit TOM70 (TOMM70A) and import into the mitochondria.
details
           
Please send any suggestions/comments to: switches@elm.eu.org