switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: ELM:LIG_SH2_IA (6 hits) x

x Coloured by: Pathway evidence source
Curated inferred

x Index

Axon guidance	ErbB signaling pathway	Fc epsilon RI signaling pathway
Natural killer cell mediated cytotoxicity	T cell receptor signaling pathway

Motif

Protein

Start

End

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Information

Evidence

Axon guidance (KEGG - hsa04360)
LIG_SH2_IA	EPHA3_HUMAN	597	606	Binary	Physicochemical compatibility	Phosphorylation of Y602 in the SH2-binding motif of Ephrin type-A receptor 3 (EPHA3) induces binding to the Cytoplasmic protein NCK1 (NCK1) protein.	details	Inferred
LIG_SH2_IA	FAK1_HUMAN	389	405	Binary	Physicochemical compatibility	Phosphorylation of Y397 in the SH2-binding motif of Focal adhesion kinase 1 (PTK2) induces binding to the Cytoplasmic protein NCK2 (NCK2) protein.	details	Inferred
ErbB signaling pathway (KEGG - hsa04012)
LIG_SH2_IA	FAK1_HUMAN	389	405	Binary	Physicochemical compatibility	Phosphorylation of Y397 in the SH2-binding motif of Focal adhesion kinase 1 (PTK2) induces binding to the Cytoplasmic protein NCK2 (NCK2) protein.	details	Inferred
Fc epsilon RI signaling pathway (KEGG - hsa04664)
LIG_SH2_IA	FCERG_HUMAN	75	79	Binary	Physicochemical compatibility	Phosphorylation of Y76 in the SH2-binding motif of High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) induces binding to the Tyrosine-protein kinase SYK (SYK) protein.	details	Curated
Natural killer cell mediated cytotoxicity (KEGG - hsa04650)
LIG_SH2_IA	FCERG_HUMAN	75	79	Binary	Physicochemical compatibility	Phosphorylation of Y76 in the SH2-binding motif of High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) induces binding to the Tyrosine-protein kinase SYK (SYK) protein.	details	Curated
T cell receptor signaling pathway (KEGG - mmu04660)
LIG_SH2_IA	LCP2_MOUSE	143	148	Binary	Physicochemical compatibility	Phosphorylation of Y145 in the SH2-binding motif of Lymphocyte cytosolic protein 2 (Lcp2) induces binding to the Tyrosine-protein kinase ITK/TSK (Itk) protein.	details	Inferred