About Help Definitions Submit Search Analyse Browse Home


Group by :Switch typeMotif classProteinEnzymePathway            Group Index    Colouring Info              Filtered: UNIPROT:P46108 (8 hits) x
submit


x  Coloured by switch type.
  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
  Uncategorised  Rheostatic  Allostery  Avidity-sensing
  Physicochemical compatibility  Pre-translational  Competition

x  Index
LIG_SH2_IBLIG_SH2_SRC


ProteinStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

LIG_SH2_IB -
DAB1_HUMAN211230BinaryPhysicochemical compatibilityPhosphorylation of Y220 in the SH2-binding motif of Disabled homolog 1 (DAB1) induces binding to the Adapter molecule crk (CRK) protein.
details
CBL_HUMAN770780BinaryPhysicochemical compatibilityPhosphorylation of Y774 in the SH2-binding motif of E3 ubiquitin-protein ligase CBL (CBL) induces binding to the Adapter molecule crk (CRK) protein.
details
BCAR1_HUMAN358368BinaryPhysicochemical compatibilityPhosphorylation of Y362 in the SH2-binding motif of Breast cancer anti-estrogen resistance protein 1 (BCAR1) induces binding to the Adapter molecule crk (CRK) protein.
details
EPHB2_MOUSE601610BinaryPhysicochemical compatibilityPhosphorylation of Y604 in the SH2-binding motif of Ephrin type-B receptor 2 (Ephb2) induces binding to the Adapter molecule crk (CRK) protein.
details
EPHB2_MOUSE606620BinaryPhysicochemical compatibilityPhosphorylation of Y610 in the SH2-binding motif of Ephrin type-B receptor 2 (Ephb2) induces binding to the Adapter molecule crk (CRK) protein.
details
PAXI_HUMAN118121BinaryPre‑translationalAlternative splicing removes the SH2-binding motif of Paxillin (PXN), abrogating binding to Adapter molecule crk (CRK).
details
PAXI_HUMAN3134BinaryPre‑translationalAlternative splicing removes the SH2-binding motif of Paxillin (PXN), abrogating binding to Adapter molecule crk (CRK).
details

LIG_SH2_SRC - Src-family Src Homology 2 (SH2) domains binding motif.
EGFR_HUMAN11251128BinaryPhysicochemical compatibilityPhosphorylation of Y1125 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to Adapter molecule crk (CRK).
details
           
Please send any suggestions/comments to: switches@elm.eu.org