switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:P00533 (14 hits) x

x Coloured by: Pathway evidence source
Curated inferred

x Index

Calcium signaling pathway	Endocytosis	ErbB signaling pathway
MAPK signaling pathway	PI3K-Akt signaling pathway

Motif

Protein

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End

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Information

Evidence

Calcium signaling pathway (KEGG - hsa04020)
LIG_SH2_SRC	EGFR_HUMAN	1016	1019	Binary	Physicochemical compatibility	Phosphorylation of Y1016 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1).	details	Curated
Endocytosis (KEGG - hsa04144)
LIG_TKB	EGFR_HUMAN	1069	1074	Binary	Physicochemical compatibility	Phosphorylation of Y1069 in Epidermal growth factor receptor (EGFR) is necessary for binding to the TKB domain of E3 ubiquitin-protein ligase CBL (CBL).	details	Inferred
TRG_ENDOCYTIC_2	EGFR_HUMAN	998	1001	Binary	Allostery	Binding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit mu (AP2M1) subunit for recruitment of Epidermal growth factor receptor (EGFR) via an endocytosis motif.	details	Inferred
LIG_TKB	EGFR_HUMAN	1069	1074	Cumulative	Rheostatic	While phosphorylation of Y1069 induces binding, additional phosphorylation of S1070 and S1071 in the TKB-binding motif of Epidermal growth factor receptor (EGFR) gradually lowers its binding affinity for E3 ubiquitin-protein ligase CBL (CBL).	details	Inferred
ErbB signaling pathway (KEGG - hsa04012)
LIG_TKB	EGFR_HUMAN	1069	1074	Binary	Physicochemical compatibility	Phosphorylation of Y1069 in Epidermal growth factor receptor (EGFR) is necessary for binding to the TKB domain of E3 ubiquitin-protein ligase CBL (CBL).	details	Inferred
LIG_TKB	EGFR_HUMAN	1069	1074	Cumulative	Rheostatic	While phosphorylation of Y1069 induces binding, additional phosphorylation of S1070 and S1071 in the TKB-binding motif of Epidermal growth factor receptor (EGFR) gradually lowers its binding affinity for E3 ubiquitin-protein ligase CBL (CBL).	details	Inferred
LIG_SH2_IC	EGFR_HUMAN	1092	1100	Binary	Physicochemical compatibility	Phosphorylation of Y1092 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Curated
LIG_SH2_SRC	EGFR_HUMAN	1016	1019	Binary	Physicochemical compatibility	Phosphorylation of Y1016 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1).	details	Curated
LIG_SH2_SRC	EGFR_HUMAN	1125	1128	Binary	Physicochemical compatibility	Phosphorylation of Y1125 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to Adapter molecule crk (CRK).	details	Curated
LIG_SH2_SRC	EGFR_HUMAN	1016	1019	Binary	Physicochemical compatibility	Phosphorylation of Y1016 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to Cytoplasmic protein NCK1 (NCK1).	details	Curated
MAPK signaling pathway (KEGG - hsa04010)
LIG_SH2_IC	EGFR_HUMAN	1092	1100	Binary	Physicochemical compatibility	Phosphorylation of Y1092 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Curated
PI3K-Akt signaling pathway (KEGG - hsa04151)
LIG_SH2_IC	EGFR_HUMAN	1092	1100	Binary	Physicochemical compatibility	Phosphorylation of Y1092 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Curated
LIG_SH2_IE	EGFR_HUMAN	1008	1024	Binary	Physicochemical compatibility	Phosphorylation of Y1016 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to the Tyrosine-protein kinase JAK1 (JAK1) protein.	details	Inferred
LIG_SH2_IE	EGFR_HUMAN	1008	1024	Binary	Physicochemical compatibility	Phosphorylation of Y1016 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to the Tyrosine-protein kinase JAK2 (JAK2) protein.	details	Inferred