switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:P62993 (16 hits) x

x Coloured by: Pathway evidence source
Curated inferred

x Index

Chemokine signaling pathway	ErbB signaling pathway	Focal adhesion
Insulin signaling pathway	MAPK signaling pathway	Natural killer cell mediated cytotoxicity
Neurotrophin signaling pathway	PI3K-Akt signaling pathway

Motif

Protein

Start

End

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Switch description

Information

Evidence

Chemokine signaling pathway (KEGG - hsa04062)
LIG_SH2_IC	SHC1_HUMAN	423	435	Binary	Physicochemical compatibility	Phosphorylation of Y427 in the SH2-binding motif of SHC-transforming protein 1 (SHC1) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Inferred
ErbB signaling pathway (KEGG - hsa04012)
LIG_SH2_IC	EGFR_HUMAN	1092	1100	Binary	Physicochemical compatibility	Phosphorylation of Y1092 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Curated
LIG_SH2_IC	SHC1_HUMAN	423	435	Binary	Physicochemical compatibility	Phosphorylation of Y427 in the SH2-binding motif of SHC-transforming protein 1 (SHC1) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Inferred
LIG_SH2_GRB2	ERBB3_HUMAN	1262	1265	Binary	Physicochemical compatibility	Phosphorylation of Y1262 in the SH2-binding motif of Receptor tyrosine-protein kinase erbB-3 (ERBB3) induces binding to Growth factor receptor-bound protein 2 (GRB2).	details	Curated
Focal adhesion (KEGG - hsa04510)
LIG_SH2_IC	MET_HUMAN	1351	1360	Binary	Physicochemical compatibility	Phosphorylation of Y1356 in the SH2-binding motif of Hepatocyte growth factor receptor (MET) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Inferred
LIG_SH2_IC	SHC1_HUMAN	423	435	Binary	Physicochemical compatibility	Phosphorylation of Y427 in the SH2-binding motif of SHC-transforming protein 1 (SHC1) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Inferred
Insulin signaling pathway (KEGG - hsa04910)
LIG_SH2_IC	SHC1_HUMAN	423	435	Binary	Physicochemical compatibility	Phosphorylation of Y427 in the SH2-binding motif of SHC-transforming protein 1 (SHC1) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Inferred
MAPK signaling pathway (KEGG - hsa04010)
LIG_SH2_IC	EGFR_HUMAN	1092	1100	Binary	Physicochemical compatibility	Phosphorylation of Y1092 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Curated
Natural killer cell mediated cytotoxicity (KEGG - hsa04650)
LIG_SH2_IC	SHC1_HUMAN	423	435	Binary	Physicochemical compatibility	Phosphorylation of Y427 in the SH2-binding motif of SHC-transforming protein 1 (SHC1) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Inferred
Neurotrophin signaling pathway (KEGG - hsa04722)
LIG_SH2_IC	SHC1_HUMAN	423	435	Binary	Physicochemical compatibility	Phosphorylation of Y427 in the SH2-binding motif of SHC-transforming protein 1 (SHC1) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Inferred
LIG_SH2_IC	FRS2_HUMAN	191	200	Binary	Physicochemical compatibility	Phosphorylation of Y196 in the SH2-binding motif of Fibroblast growth factor receptor substrate 2 (FRS2) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Inferred
LIG_SH2_IC	FRS2_HUMAN	301	310	Binary	Physicochemical compatibility	Phosphorylation of Y306 in the SH2-binding motif of Fibroblast growth factor receptor substrate 2 (FRS2) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Inferred
LIG_SH2_IC	FRS2_HUMAN	345	355	Binary	Physicochemical compatibility	Phosphorylation of Y349 in the SH2-binding motif of Fibroblast growth factor receptor substrate 2 (FRS2) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Inferred
LIG_SH2_IC	FRS2_HUMAN	385	395	Binary	Physicochemical compatibility	Phosphorylation of Y392 in the SH2-binding motif of Fibroblast growth factor receptor substrate 2 (FRS2) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Inferred
PI3K-Akt signaling pathway (KEGG - hsa04151)
LIG_SH2_IC	EGFR_HUMAN	1092	1100	Binary	Physicochemical compatibility	Phosphorylation of Y1092 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Curated
LIG_SH2_IC	MET_HUMAN	1351	1360	Binary	Physicochemical compatibility	Phosphorylation of Y1356 in the SH2-binding motif of Hepatocyte growth factor receptor (MET) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Inferred