switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:P62993 (19 hits) x

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Curated inferred

x Index

Cyclin-dependent kinase 1	Epidermal growth factor receptor	Glycogen synthase kinase-3 beta
Hepatocyte growth factor receptor	Macrophage-stimulating protein receptor	Neuronal proto-oncogene tyrosine-protein kinase Src (Mus)
Proto-oncogene tyrosine-protein kinase Src	Tyrosine-protein kinase ABL1	Tyrosine-protein kinase Fyn
Tyrosine-protein kinase SYK	Tyrosine-protein kinase ZAP-70	Vascular endothelial growth factor receptor 3

Motif

Protein

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Information

Evidence

Cyclin-dependent kinase 1 - CDK1 - Homo sapiens
LIG_SH2_GRB2	A4_HUMAN	757	760	Cumulative	Rheostatic	While phosphorylation of Y757 in the SH2-binding motif of Amyloid beta A4 protein (APP) induces binding to Growth factor receptor-bound protein 2 (GRB2), additional phosphorylation of T743 further increases the strength of the interaction.	details	Inferred
Epidermal growth factor receptor - EGFR - Homo sapiens
LIG_SH2_IC	EGFR_HUMAN	1092	1100	Binary	Physicochemical compatibility	Phosphorylation of Y1092 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Inferred
LIG_SH2_IC	EGFR_HUMAN	1092	1100	Binary	Physicochemical compatibility	Phosphorylation of Y1092 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Inferred
Glycogen synthase kinase-3 beta - GSK3B - Homo sapiens
LIG_SH2_GRB2	A4_HUMAN	757	760	Cumulative	Rheostatic	While phosphorylation of Y757 in the SH2-binding motif of Amyloid beta A4 protein (APP) induces binding to Growth factor receptor-bound protein 2 (GRB2), additional phosphorylation of T743 further increases the strength of the interaction.	details	Inferred
Hepatocyte growth factor receptor - MET - Homo sapiens
LIG_SH2_IC	MET_HUMAN	1351	1360	Binary	Physicochemical compatibility	Phosphorylation of Y1356 in the SH2-binding motif of Hepatocyte growth factor receptor (MET) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Inferred
LIG_SH2_IC	MET_HUMAN	1351	1360	Binary	Physicochemical compatibility	Phosphorylation of Y1356 in the SH2-binding motif of Hepatocyte growth factor receptor (MET) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Inferred
LIG_SH2_IC	MET_HUMAN	1351	1360	Binary	Physicochemical compatibility	Phosphorylation of Y1356 in the SH2-binding motif of Hepatocyte growth factor receptor (MET) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Inferred
LIG_SH2_IC	MET_HUMAN	1351	1360	Binary	Physicochemical compatibility	Phosphorylation of Y1356 in the SH2-binding motif of Hepatocyte growth factor receptor (MET) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Inferred
LIG_SH2_IC	SHC1_HUMAN	423	435	Binary	Physicochemical compatibility	Phosphorylation of Y427 in the SH2-binding motif of SHC-transforming protein 1 (SHC1) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Inferred
Macrophage-stimulating protein receptor - MST1R - Homo sapiens
LIG_SH2_IC	MET_HUMAN	1351	1360	Binary	Physicochemical compatibility	Phosphorylation of Y1356 in the SH2-binding motif of Hepatocyte growth factor receptor (MET) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Inferred
Neuronal proto-oncogene tyrosine-protein kinase Src - SRC - Mus musculus
LIG_SH2_IC	EGFR_HUMAN	1092	1100	Binary	Physicochemical compatibility	Phosphorylation of Y1092 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Inferred
Proto-oncogene tyrosine-protein kinase Src - SRC - Homo sapiens
LIG_SH2_IC	SHC1_HUMAN	423	435	Binary	Physicochemical compatibility	Phosphorylation of Y427 in the SH2-binding motif of SHC-transforming protein 1 (SHC1) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Inferred
Tyrosine-protein kinase ABL1 - ABL1 - Homo sapiens
LIG_SH2_IC	EGFR_HUMAN	1092	1100	Binary	Physicochemical compatibility	Phosphorylation of Y1092 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Inferred
LIG_SH2_IC	MET_HUMAN	1351	1360	Binary	Physicochemical compatibility	Phosphorylation of Y1356 in the SH2-binding motif of Hepatocyte growth factor receptor (MET) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Inferred
Tyrosine-protein kinase Fyn - FYN - Homo sapiens
LIG_SH2_GRB2	A4_HUMAN	757	760	Cumulative	Rheostatic	While phosphorylation of Y757 in the SH2-binding motif of Amyloid beta A4 protein (APP) induces binding to Growth factor receptor-bound protein 2 (GRB2), additional phosphorylation of T743 further increases the strength of the interaction.	details	Inferred
LIG_SH2_GRB2	A4_HUMAN	757	760	Specificity	Altered binding specificity	Phosphorylation of Y757 in APP (Amyloid beta A4 protein (APP)) switches its specificity from PTB domain containing proteins, like Amyloid beta A4 precursor protein-binding family B member 1 (APBB1), which is involved in trafficking and processing of APP, to SH2 domain containing proteins, such as Growth factor receptor-bound protein 2 (GRB2).	details	Inferred
Tyrosine-protein kinase SYK - SYK - Homo sapiens
LIG_SH2_IC	SHC1_HUMAN	423	435	Binary	Physicochemical compatibility	Phosphorylation of Y427 in the SH2-binding motif of SHC-transforming protein 1 (SHC1) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Inferred
Tyrosine-protein kinase ZAP-70 - ZAP70 - Homo sapiens
LIG_SH2_IC	SHC1_HUMAN	423	435	Binary	Physicochemical compatibility	Phosphorylation of Y427 in the SH2-binding motif of SHC-transforming protein 1 (SHC1) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Inferred
Vascular endothelial growth factor receptor 3 - FLT4 - Homo sapiens
LIG_SH2_IC	SHC1_HUMAN	423	435	Binary	Physicochemical compatibility	Phosphorylation of Y427 in the SH2-binding motif of SHC-transforming protein 1 (SHC1) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Inferred