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Group by :Switch typeMotif classProteinEnzymePathway         Hide inferred   Group Index    Colouring Info              Filtered: UNIPROT:P62993 (16 hits) x


x  Coloured by: Pathway evidence source
          Curated          inferred


x  Index
Chemokine signaling pathwayErbB signaling pathwayFocal adhesion
Insulin signaling pathwayMAPK signaling pathwayNatural killer cell mediated cytotoxicity
Neurotrophin signaling pathwayPI3K-Akt signaling pathway


MotifProteinStartEndSwitch TypeSwitch SubtypeSwitch descriptionInformationEvidence

Chemokine signaling pathway (KEGG - hsa04062)
LIG_SH2_IC SHC1_HUMAN423435BinaryPhysicochemical compatibilityPhosphorylation of Y427 in the SH2-binding motif of SHC-transforming protein 1 (SHC1) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.
details
Inferred

ErbB signaling pathway (KEGG - hsa04012)
LIG_SH2_IC EGFR_HUMAN10921100BinaryPhysicochemical compatibilityPhosphorylation of Y1092 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.
details
Curated
LIG_SH2_IC SHC1_HUMAN423435BinaryPhysicochemical compatibilityPhosphorylation of Y427 in the SH2-binding motif of SHC-transforming protein 1 (SHC1) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.
details
Inferred
LIG_SH2_GRB2 ERBB3_HUMAN12621265BinaryPhysicochemical compatibilityPhosphorylation of Y1262 in the SH2-binding motif of Receptor tyrosine-protein kinase erbB-3 (ERBB3) induces binding to Growth factor receptor-bound protein 2 (GRB2).
details
Curated

Focal adhesion (KEGG - hsa04510)
LIG_SH2_IC MET_HUMAN13511360BinaryPhysicochemical compatibilityPhosphorylation of Y1356 in the SH2-binding motif of Hepatocyte growth factor receptor (MET) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.
details
Inferred
LIG_SH2_IC SHC1_HUMAN423435BinaryPhysicochemical compatibilityPhosphorylation of Y427 in the SH2-binding motif of SHC-transforming protein 1 (SHC1) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.
details
Inferred

Insulin signaling pathway (KEGG - hsa04910)
LIG_SH2_IC SHC1_HUMAN423435BinaryPhysicochemical compatibilityPhosphorylation of Y427 in the SH2-binding motif of SHC-transforming protein 1 (SHC1) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.
details
Inferred

MAPK signaling pathway (KEGG - hsa04010)
LIG_SH2_IC EGFR_HUMAN10921100BinaryPhysicochemical compatibilityPhosphorylation of Y1092 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.
details
Curated

Natural killer cell mediated cytotoxicity (KEGG - hsa04650)
LIG_SH2_IC SHC1_HUMAN423435BinaryPhysicochemical compatibilityPhosphorylation of Y427 in the SH2-binding motif of SHC-transforming protein 1 (SHC1) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.
details
Inferred

Neurotrophin signaling pathway (KEGG - hsa04722)
LIG_SH2_IC SHC1_HUMAN423435BinaryPhysicochemical compatibilityPhosphorylation of Y427 in the SH2-binding motif of SHC-transforming protein 1 (SHC1) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.
details
Inferred
LIG_SH2_IC FRS2_HUMAN191200BinaryPhysicochemical compatibilityPhosphorylation of Y196 in the SH2-binding motif of Fibroblast growth factor receptor substrate 2 (FRS2) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.
details
Inferred
LIG_SH2_IC FRS2_HUMAN301310BinaryPhysicochemical compatibilityPhosphorylation of Y306 in the SH2-binding motif of Fibroblast growth factor receptor substrate 2 (FRS2) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.
details
Inferred
LIG_SH2_IC FRS2_HUMAN345355BinaryPhysicochemical compatibilityPhosphorylation of Y349 in the SH2-binding motif of Fibroblast growth factor receptor substrate 2 (FRS2) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.
details
Inferred
LIG_SH2_IC FRS2_HUMAN385395BinaryPhysicochemical compatibilityPhosphorylation of Y392 in the SH2-binding motif of Fibroblast growth factor receptor substrate 2 (FRS2) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.
details
Inferred

PI3K-Akt signaling pathway (KEGG - hsa04151)
LIG_SH2_IC EGFR_HUMAN10921100BinaryPhysicochemical compatibilityPhosphorylation of Y1092 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.
details
Curated
LIG_SH2_IC MET_HUMAN13511360BinaryPhysicochemical compatibilityPhosphorylation of Y1356 in the SH2-binding motif of Hepatocyte growth factor receptor (MET) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.
details
Inferred
           
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