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| Domain hiding | Altered binding specificity | Motif hiding | Composite binding site formation |
| Uncategorised | Rheostatic | Allostery | Avidity-sensing |
| Physicochemical compatibility | Pre-translational | Competition |
| Motif | Start | End | Switch Type | Switch Subtype | Switch Description | Information |
Amyloid beta A4 protein - APP - Homo sapiens | |||||||
| LIG_SH2_GRB2 | 757 | 760 | Cumulative | Rheostatic | While phosphorylation of Y757 in the SH2-binding motif of Amyloid beta A4 protein (APP) induces binding to Growth factor receptor-bound protein 2 (GRB2), additional phosphorylation of T743 further increases the strength of the interaction. | ||
| LIG_SH2_GRB2 | 757 | 760 | Specificity | Altered binding specificity | Phosphorylation of Y757 in APP (Amyloid beta A4 protein (APP)) switches its specificity from PTB domain containing proteins, like Amyloid beta A4 precursor protein-binding family B member 1 (APBB1), which is involved in trafficking and processing of APP, to SH2 domain containing proteins, such as Growth factor receptor-bound protein 2 (GRB2). | ||
BCR/ABL fusion - - Homo sapiens | |||||||
| LIG_SH2_IC | 174 | 180 | Binary | Physicochemical compatibility | Phosphorylation of Y177 in the SH2-binding motif of BCR/ABL fusion induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein. | ||
Dystroglycan - DAG1 - Homo sapiens | |||||||
| LIG_WW_1 | 889 | 892 | Specificity | Competition | The WW-binding motif for Dystrophin (DMD) and the SH3-binding motif for Growth factor receptor-bound protein 2 (GRB2) on Dystroglycan (DAG1) overlap, making their interactions mutually exclusive and competitive. | ||
| LIG_SH3_3 | 888 | 894 | Specificity | Competition | The WW-binding motif for Dystrophin (DMD) and the SH3-binding motif for Growth factor receptor-bound protein 2 (GRB2) on Dystroglycan (DAG1) overlap, making their interactions mutually exclusive and competitive. | ||
| LIG_WW_1 | 889 | 892 | Specificity | Competition | The WW-binding motif for Dystrophin (DMD) and the SH3-binding motif for Growth factor receptor-bound protein 2 (GRB2) on Dystroglycan (DAG1) overlap, making their interactions mutually exclusive and competitive. | ||
| LIG_SH3_3 | 888 | 894 | Specificity | Competition | The WW-binding motif for Dystrophin (DMD) and the SH3-binding motif for Growth factor receptor-bound protein 2 (GRB2) on Dystroglycan (DAG1) overlap, making their interactions mutually exclusive and competitive. | ||
Epidermal growth factor receptor - EGFR - Homo sapiens | |||||||
| LIG_SH2_IC | 1092 | 1100 | Binary | Physicochemical compatibility | Phosphorylation of Y1092 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein. | ||
Fibroblast growth factor receptor substrate 2 - FRS2 - Homo sapiens | |||||||
| LIG_SH2_IC | 191 | 200 | Binary | Physicochemical compatibility | Phosphorylation of Y196 in the SH2-binding motif of Fibroblast growth factor receptor substrate 2 (FRS2) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein. | ||
| LIG_SH2_IC | 301 | 310 | Binary | Physicochemical compatibility | Phosphorylation of Y306 in the SH2-binding motif of Fibroblast growth factor receptor substrate 2 (FRS2) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein. | ||
| LIG_SH2_IC | 345 | 355 | Binary | Physicochemical compatibility | Phosphorylation of Y349 in the SH2-binding motif of Fibroblast growth factor receptor substrate 2 (FRS2) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein. | ||
| LIG_SH2_IC | 385 | 395 | Binary | Physicochemical compatibility | Phosphorylation of Y392 in the SH2-binding motif of Fibroblast growth factor receptor substrate 2 (FRS2) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein. | ||
Hepatocyte growth factor receptor - MET - Homo sapiens | |||||||
| LIG_SH2_IC | 1351 | 1360 | Binary | Physicochemical compatibility | Phosphorylation of Y1356 in the SH2-binding motif of Hepatocyte growth factor receptor (MET) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein. | ||
Receptor tyrosine-protein kinase erbB-3 - ERBB3 - Homo sapiens | |||||||
| LIG_SH2_GRB2 | 1262 | 1265 | Binary | Physicochemical compatibility | Phosphorylation of Y1262 in the SH2-binding motif of Receptor tyrosine-protein kinase erbB-3 (ERBB3) induces binding to Growth factor receptor-bound protein 2 (GRB2). | ||
SHC-transforming protein 1 - SHC1 - Homo sapiens | |||||||
| LIG_SH2_IC | 423 | 435 | Binary | Physicochemical compatibility | Phosphorylation of Y427 in the SH2-binding motif of SHC-transforming protein 1 (SHC1) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein. | ||