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Group by :Switch typeMotif classProteinEnzymePathway            Group Index    Colouring Info              Filtered: UNIPROT:P31946 (10 hits) x
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  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
  Uncategorised  Rheostatic  Allostery  Avidity-sensing
  Physicochemical compatibility  Pre-translational  Competition

x  Index
Bcl2 antagonist of cell death (Rattus)Disintegrin and metalloproteinase domain-containing protein 22G-protein coupled receptor 15
HLA class II histocompatibility antigen gamma chainHistone deacetylase 4M-phase inducer phosphatase 2
M-phase inducer phosphatase 3


MotifStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

Bcl2 antagonist of cell death - Bad -  Rattus norvegicus
LIG_14-3-3_1134139BinaryPhysicochemical compatibilityPhosphorylation of S137 by RAC-alpha serine/threonine-protein kinase (Akt1) in the 14-3-3-binding motif of Bcl2 antagonist of cell death (Bad) induces binding to the 14-3-3 protein beta/alpha (YWHAB) protein. This interaction inhibits the pro-apoptotic activity of Bcl2 antagonist of cell death (Bad).
details

Disintegrin and metalloproteinase domain-containing protein 22 - ADAM22 -  Homo sapiens
LIG_14-3-3_3831
854		836
859		SpecificityMotif hidingPhosphorylation-induced binding of dimeric 14-3-3 protein beta/alpha (YWHAB) to Disintegrin and metalloproteinase domain-containing protein 22 (ADAM22) blocks ER retention motifs in Disintegrin and metalloproteinase domain-containing protein 22 (ADAM22) and regulates transport of this protein to the membrane.
details
TRG_ER_diArg_1829
851		831
854		SpecificityMotif hidingPhosphorylation-induced binding of dimeric 14-3-3 protein beta/alpha (YWHAB) to Disintegrin and metalloproteinase domain-containing protein 22 (ADAM22) blocks ER retention motifs in Disintegrin and metalloproteinase domain-containing protein 22 (ADAM22) and regulates transport of this protein to the membrane.
details

G-protein coupled receptor 15 - GPR15 -  Homo sapiens
LIG_14-3-3_4356360SpecificityMotif hidingPhosphorylation-induced binding of 14-3-3 protein beta/alpha (YWHAB) promotes cell surface expression of G-protein coupled receptor 15 (GPR15) by releasing the receptor from the ER retrieval/retention pathway that is mediated by the interaction of its ER retention motif with Coatomer subunit beta (COPB1).
details
TRG_ER_diArg_1352354SpecificityMotif hidingPhosphorylation-induced binding of 14-3-3 protein beta/alpha (YWHAB) promotes cell surface expression of G-protein coupled receptor 15 (GPR15) by releasing the receptor from the ER retrieval/retention pathway that is mediated by the interaction of its ER retention motif with Coatomer subunit beta (COPB1).
details

HLA class II histocompatibility antigen gamma chain - CD74 -  Homo sapiens
LIG_14-3-3_3510SpecificityMotif hidingThe basic ER retention motif of HLA class II histocompatibility antigen gamma chain (CD74) is blocked from binding to Coatomer subunit beta (COPB1) by phosphorylation-induced binding of 14-3-3 protein beta/alpha (YWHAB), regulating its release from the ER and trafficking to the plasma membrane.
details
TRG_ER_diArg_135SpecificityMotif hidingThe basic ER retention motif of HLA class II histocompatibility antigen gamma chain (CD74) is blocked from binding to Coatomer subunit beta (COPB1) by phosphorylation-induced binding of 14-3-3 protein beta/alpha (YWHAB), regulating its release from the ER and trafficking to the plasma membrane.
details

Histone deacetylase 4 - HDAC4 -  Homo sapiens
LIG_14-3-3_3629634BinaryPhysicochemical compatibilityPhosphorylation of S632 in the 14-3-3-binding motif of Histone deacetylase 4 (HDAC4) induces binding to the 14-3-3 protein beta/alpha (YWHAB) protein. This interaction sequesters Histone deacetylase 4 (HDAC4) in the cytoplasm, thereby inhibiting their transcription repression activity.
details

M-phase inducer phosphatase 2 - CDC25B -  Homo sapiens
LIG_14-3-3_3320325BinaryPhysicochemical compatibilityPhosphorylation of S321 in the 14-3-3-binding motif of M-phase inducer phosphatase 2 (CDC25B) by Cyclin-dependent kinase 1 (CDK1) during mitosis abolishes binding of the motif, phosphorylated at S323, to 14-3-3 protein beta/alpha (YWHAB), thereby maintaining active Cdc25B.
details

M-phase inducer phosphatase 3 - CDC25C -  Homo sapiens
LIG_14-3-3_3213218BinaryPhysicochemical compatibilityPhosphorylation of S216 in a 14-3-3-binding motif of M-phase inducer phosphatase 3 (CDC25C) by Serine/threonine-protein kinase Chk1 (CHEK1) induces binding to 14-3-3 protein beta/alpha (YWHAB), which negatively regulates M-phase inducer phosphatase 3 (CDC25C).
details
           
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