switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:P29353 (15 hits) x

x Coloured by: Pathway evidence source
Curated inferred

x Index

Chemokine signaling pathway	ErbB signaling pathway	Focal adhesion
Insulin signaling pathway	Natural killer cell mediated cytotoxicity	Neurotrophin signaling pathway

Motif

Protein

Start

End

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Information

Evidence

Chemokine signaling pathway (KEGG - hsa04062)
LIG_SH2_IC	SHC1_HUMAN	423	435	Binary	Physicochemical compatibility	Phosphorylation of Y427 in the SH2-binding motif of SHC-transforming protein 1 (SHC1) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Inferred
ErbB signaling pathway (KEGG - hsa04012)
LIG_PTB_Phospho_1	ERBB3_HUMAN	1322	1328	Binary	Physicochemical compatibility	Phosphorylation of Y1328 in the PTB-binding motif of Receptor tyrosine-protein kinase erbB-3 (ERBB3) induces binding to the SHC-transforming protein 1 (SHC1) protein.	details	Inferred
LIG_SH2_IC	SHC1_HUMAN	423	435	Binary	Physicochemical compatibility	Phosphorylation of Y427 in the SH2-binding motif of SHC-transforming protein 1 (SHC1) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Inferred
Focal adhesion (KEGG - hsa04510)
LIG_PTB_Phospho_1	ITB3_HUMAN	779	785	Binary	Physicochemical compatibility	Phosphorylation of Y785 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to the SHC-transforming protein 1 (SHC1) protein.	details	Inferred
LIG_PTB_Phospho_1	ITB4_HUMAN	1590	1596	Binary	Physicochemical compatibility	Phosphorylation of Y1596 in the PTB-binding motif of Integrin beta-4 (ITGB4) induces binding to the SHC-transforming protein 1 (SHC1) protein.	details	Inferred
LIG_PTB_Phospho_1	ITB3_HUMAN	779	785	Binary	Physicochemical compatibility	Phosphorylation of T779 in the PTB-binding motif of Integrin beta-3 (ITGB3) inhibits its interaction with SHC-transforming protein 1 (SHC1).	details	Inferred
LIG_PTB_Phospho_1	ITB3_HUMAN	779	785	Cumulative	Rheostatic	While phosphorylation of Y785 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to SHC-transforming protein 1 (SHC1), additional phosphorylation of Y773 further increases the strength of the interaction.	details	Inferred
LIG_PTB_Phospho_1	ITB3_HUMAN	779	785	Specificity	Altered binding specificity	Phosphorylation of Integrin beta-3 (ITGB3) at Y785 switches the specificity of integrin from Kindlin-2 (Fermitin family homolog 2 (FERMT2)) to the adaptor protein SHC-transforming protein 1 (SHC1).	details	Inferred
LIG_SH2_IC	SHC1_HUMAN	423	435	Binary	Physicochemical compatibility	Phosphorylation of Y427 in the SH2-binding motif of SHC-transforming protein 1 (SHC1) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Inferred
Insulin signaling pathway (KEGG - hsa04910)
LIG_PTB_Phospho_1	INSR_HUMAN	993	999	Binary	Physicochemical compatibility	Phosphorylation of Y999 in the PTB-binding motif of Insulin receptor (INSR) induces binding to the SHC-transforming protein 1 (SHC1) protein.	details	Inferred
LIG_SH2_IC	SHC1_HUMAN	423	435	Binary	Physicochemical compatibility	Phosphorylation of Y427 in the SH2-binding motif of SHC-transforming protein 1 (SHC1) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Inferred
Natural killer cell mediated cytotoxicity (KEGG - hsa04650)
LIG_SH2_IC	SHC1_HUMAN	423	435	Binary	Physicochemical compatibility	Phosphorylation of Y427 in the SH2-binding motif of SHC-transforming protein 1 (SHC1) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Inferred
Neurotrophin signaling pathway (KEGG - hsa04722)
LIG_PTB_Phospho_1	NTRK1_HUMAN	490	496	Binary	Physicochemical compatibility	Phosphorylation of Y496 in the PTB-binding motif of High affinity nerve growth factor receptor (NTRK1) induces binding to the SHC-transforming protein 1 (SHC1) protein.	details	Inferred
LIG_SH2_IIB	NTRK1_HUMAN	782	796	Binary	Physicochemical compatibility	Phosphorylation of Y791 in the SH2-binding motif of High affinity nerve growth factor receptor (NTRK1) induces binding to the SHC-transforming protein 1 (SHC1) protein.	details	Inferred
LIG_SH2_IC	SHC1_HUMAN	423	435	Binary	Physicochemical compatibility	Phosphorylation of Y427 in the SH2-binding motif of SHC-transforming protein 1 (SHC1) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Inferred