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Aurora kinase ACDC2/CDKX subfamily ()Cyclin-dependent kinase 1
Cyclin-dependent kinase 2Cyclin-dependent kinase 2 (Mus)Cyclin-dependent kinase 3
Cyclin-dependent kinase 4Cyclin-dependent kinase 4 (Mus)Cyclin-dependent kinase 5
Cyclin-dependent kinase 6Cyclin-dependent kinase 7Cyclin-dependent kinase 8
Cyclin-dependent kinase 9Glycogen synthase kinase-3 alphaGlycogen synthase kinase-3 beta
Glycogen synthase kinase-3 beta (Rattus)Interleukin-1 receptor-associated kinase 1Interleukin-1 receptor-associated kinase 4
Maternal embryonic leucine zipper kinase (Mus)Mitogen-activated protein kinase 1Mitogen-activated protein kinase 10
Mitogen-activated protein kinase 14Mitogen-activated protein kinase 15Mitogen-activated protein kinase 3
Mitogen-activated protein kinase 7Mitogen-activated protein kinase 8Mitogen-activated protein kinase 9
Mitogen-activated protein kinase 9Protein kinase C delta typeProtein kinase C epsilon type
Ribosomal protein S6 kinase alpha-3Serine/threonine-protein kinase D1Serine/threonine-protein kinase PLK3
Serine/threonine-protein kinase VRK1Serine/threonine-protein kinase mTORSerine/threonine-protein kinase mTOR (Mus)


MotifProteinStartEndSwitch TypeSwitch SubtypeSwitch descriptionInformationEvidence

CDC2/CDKX subfamily
DOC_WW_Pin1_4 SMAD3_HUMAN176181SpecificityAltered binding specificityCDK8/9 phosphorylates Mothers against decapentaplegic homolog 3 (SMAD3) at T179 and S208. Phosphorylation of T179 creates a binding site for the WW domain of Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1), while phosphorylation of S208 primes SMAD3 for phosphorylation of S204 by Glycogen synthase kinase-3 beta (GSK3B). The pS204-pS208 forms a binding site for the third WW domain of E3 ubiquitin-protein ligase NEDD4-like (NEDD4L), whose second WW domain will displace the WW domain of PIN1 at the pT179-PY box site of SMAD3. This regulation couples SMAD3 activation to SMAD3 destruction in an ordered fashion. See also switch details and switch details.
details
Curated

Aurora kinase A - AURKA -  Homo sapiens
DOC_WW_Pin1_4 P53_HUMAN312317BinaryPhysicochemical compatibilityPhosphorylation of S315 in the Pin1-binding motif of Cellular tumor antigen p53 (TP53) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 P53_HUMAN312317BinaryPhysicochemical compatibilityPhosphorylation of S315 in the Pin1-binding motif of Cellular tumor antigen p53 (TP53) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred

Cyclin-dependent kinase 1 - CDK1 -  Homo sapiens
DOC_WW_Pin1_4 P53_HUMAN312317BinaryPhysicochemical compatibilityPhosphorylation of S315 in the Pin1-binding motif of Cellular tumor antigen p53 (TP53) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred

Cyclin-dependent kinase 2 - CDK2 -  Homo sapiens
DOC_WW_Pin1_4 P53_HUMAN312317BinaryPhysicochemical compatibilityPhosphorylation of S315 in the Pin1-binding motif of Cellular tumor antigen p53 (TP53) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 CDN1B_HUMAN184189BinaryPhysicochemical compatibilityPhosphorylation of T187 in the Pin1-binding motif of Cyclin-dependent kinase inhibitor 1B (CDKN1B) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 CDN1B_HUMAN184189BinaryPhysicochemical compatibilityPhosphorylation of T187 in the Pin1-binding motif of Cyclin-dependent kinase inhibitor 1B (CDKN1B) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 SMAD3_HUMAN176181BinaryPhysicochemical compatibilityPhosphorylation of T179 in the Pin1-binding motif of Mothers against decapentaplegic homolog 3 (SMAD3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 SMAD3_HUMAN210215BinaryPhysicochemical compatibilityPhosphorylation of S213 in the Pin1-binding motif of Mothers against decapentaplegic homolog 3 (SMAD3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 SMAD3_HUMAN176181SpecificityAltered binding specificityCDK8/9 phosphorylates Mothers against decapentaplegic homolog 3 (SMAD3) at T179 and S208. Phosphorylation of T179 creates a binding site for the WW domain of Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1), while phosphorylation of S208 primes SMAD3 for phosphorylation of S204 by Glycogen synthase kinase-3 beta (GSK3B). The pS204-pS208 forms a binding site for the third WW domain of E3 ubiquitin-protein ligase NEDD4-like (NEDD4L), whose second WW domain will displace the WW domain of PIN1 at the pT179-PY box site of SMAD3. This regulation couples SMAD3 activation to SMAD3 destruction in an ordered fashion. See also switch details and switch details.
details
Inferred

Cyclin-dependent kinase 2 - CDK2 -  Mus musculus
DOC_WW_Pin1_4 CDN1B_HUMAN184189BinaryPhysicochemical compatibilityPhosphorylation of T187 in the Pin1-binding motif of Cyclin-dependent kinase inhibitor 1B (CDKN1B) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 SMAD3_HUMAN176181BinaryPhysicochemical compatibilityPhosphorylation of T179 in the Pin1-binding motif of Mothers against decapentaplegic homolog 3 (SMAD3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 SMAD3_HUMAN210215BinaryPhysicochemical compatibilityPhosphorylation of S213 in the Pin1-binding motif of Mothers against decapentaplegic homolog 3 (SMAD3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 SMAD3_HUMAN176181SpecificityAltered binding specificityCDK8/9 phosphorylates Mothers against decapentaplegic homolog 3 (SMAD3) at T179 and S208. Phosphorylation of T179 creates a binding site for the WW domain of Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1), while phosphorylation of S208 primes SMAD3 for phosphorylation of S204 by Glycogen synthase kinase-3 beta (GSK3B). The pS204-pS208 forms a binding site for the third WW domain of E3 ubiquitin-protein ligase NEDD4-like (NEDD4L), whose second WW domain will displace the WW domain of PIN1 at the pT179-PY box site of SMAD3. This regulation couples SMAD3 activation to SMAD3 destruction in an ordered fashion. See also switch details and switch details.
details
Inferred

Cyclin-dependent kinase 3 - CDK3 -  Homo sapiens
DOC_WW_Pin1_4 JUN_HUMAN6065BinaryPhysicochemical compatibilityPhosphorylation of S63 in the Pin1-binding motif of Transcription factor AP-1 (JUN) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 JUN_HUMAN7075BinaryPhysicochemical compatibilityPhosphorylation of S73 in the Pin1-binding motif of Transcription factor AP-1 (JUN) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred

Cyclin-dependent kinase 4 - CDK4 -  Homo sapiens
DOC_WW_Pin1_4 SMAD3_HUMAN176181BinaryPhysicochemical compatibilityPhosphorylation of T179 in the Pin1-binding motif of Mothers against decapentaplegic homolog 3 (SMAD3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 SMAD3_HUMAN176181BinaryPhysicochemical compatibilityPhosphorylation of T179 in the Pin1-binding motif of Mothers against decapentaplegic homolog 3 (SMAD3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 SMAD3_HUMAN201206BinaryPhysicochemical compatibilityPhosphorylation of S204 in the Pin1-binding motif of Mothers against decapentaplegic homolog 3 (SMAD3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 SMAD3_HUMAN205210BinaryPhysicochemical compatibilityPhosphorylation of S208 in the Pin1-binding motif of Mothers against decapentaplegic homolog 3 (SMAD3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 SMAD3_HUMAN210215BinaryPhysicochemical compatibilityPhosphorylation of S213 in the Pin1-binding motif of Mothers against decapentaplegic homolog 3 (SMAD3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 SMAD3_HUMAN210215BinaryPhysicochemical compatibilityPhosphorylation of S213 in the Pin1-binding motif of Mothers against decapentaplegic homolog 3 (SMAD3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 SMAD3_HUMAN176181SpecificityAltered binding specificityCDK8/9 phosphorylates Mothers against decapentaplegic homolog 3 (SMAD3) at T179 and S208. Phosphorylation of T179 creates a binding site for the WW domain of Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1), while phosphorylation of S208 primes SMAD3 for phosphorylation of S204 by Glycogen synthase kinase-3 beta (GSK3B). The pS204-pS208 forms a binding site for the third WW domain of E3 ubiquitin-protein ligase NEDD4-like (NEDD4L), whose second WW domain will displace the WW domain of PIN1 at the pT179-PY box site of SMAD3. This regulation couples SMAD3 activation to SMAD3 destruction in an ordered fashion. See also switch details and switch details.
details
Inferred
DOC_WW_Pin1_4 SMAD3_HUMAN176181SpecificityAltered binding specificityCDK8/9 phosphorylates Mothers against decapentaplegic homolog 3 (SMAD3) at T179 and S208. Phosphorylation of T179 creates a binding site for the WW domain of Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1), while phosphorylation of S208 primes SMAD3 for phosphorylation of S204 by Glycogen synthase kinase-3 beta (GSK3B). The pS204-pS208 forms a binding site for the third WW domain of E3 ubiquitin-protein ligase NEDD4-like (NEDD4L), whose second WW domain will displace the WW domain of PIN1 at the pT179-PY box site of SMAD3. This regulation couples SMAD3 activation to SMAD3 destruction in an ordered fashion. See also switch details and switch details.
details
Inferred

Cyclin-dependent kinase 4 - CDK4 -  Mus musculus
DOC_WW_Pin1_4 SMAD3_HUMAN176181BinaryPhysicochemical compatibilityPhosphorylation of T179 in the Pin1-binding motif of Mothers against decapentaplegic homolog 3 (SMAD3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 SMAD3_HUMAN210215BinaryPhysicochemical compatibilityPhosphorylation of S213 in the Pin1-binding motif of Mothers against decapentaplegic homolog 3 (SMAD3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 SMAD3_HUMAN176181SpecificityAltered binding specificityCDK8/9 phosphorylates Mothers against decapentaplegic homolog 3 (SMAD3) at T179 and S208. Phosphorylation of T179 creates a binding site for the WW domain of Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1), while phosphorylation of S208 primes SMAD3 for phosphorylation of S204 by Glycogen synthase kinase-3 beta (GSK3B). The pS204-pS208 forms a binding site for the third WW domain of E3 ubiquitin-protein ligase NEDD4-like (NEDD4L), whose second WW domain will displace the WW domain of PIN1 at the pT179-PY box site of SMAD3. This regulation couples SMAD3 activation to SMAD3 destruction in an ordered fashion. See also switch details and switch details.
details
Inferred

Cyclin-dependent kinase 5 - CDK5 -  Homo sapiens
DOC_WW_Pin1_4 CTNB1_HUMAN243248BinaryPhysicochemical compatibilityPhosphorylation of S246 in the Pin1-binding motif of Catenin beta-1 (CTNNB1) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 FAK1_HUMAN907912BinaryPhysicochemical compatibilityPhosphorylation of S910 in the Pin1-binding motif of Focal adhesion kinase 1 (PTK2) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred

Cyclin-dependent kinase 6 - CDK6 -  Homo sapiens
DOC_WW_Pin1_4 CDN1B_HUMAN184189BinaryPhysicochemical compatibilityPhosphorylation of T187 in the Pin1-binding motif of Cyclin-dependent kinase inhibitor 1B (CDKN1B) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred

Cyclin-dependent kinase 7 - CDK7 -  Homo sapiens
DOC_WW_Pin1_4 RARA_HUMAN7479BinaryPhysicochemical compatibilityPhosphorylation of S77 in the Pin1-binding motif of Retinoic acid receptor alpha (RARA) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 RARA_HUMAN7479BinaryPhysicochemical compatibilityPhosphorylation of S77 in the Pin1-binding motif of Retinoic acid receptor alpha (RARA) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred

Cyclin-dependent kinase 8 - CDK8 -  Homo sapiens
DOC_WW_Pin1_4 SMAD3_HUMAN176181BinaryPhysicochemical compatibilityPhosphorylation of T179 in the Pin1-binding motif of Mothers against decapentaplegic homolog 3 (SMAD3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 SMAD3_HUMAN205210BinaryPhysicochemical compatibilityPhosphorylation of S208 in the Pin1-binding motif of Mothers against decapentaplegic homolog 3 (SMAD3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 SMAD3_HUMAN210215BinaryPhysicochemical compatibilityPhosphorylation of S213 in the Pin1-binding motif of Mothers against decapentaplegic homolog 3 (SMAD3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 SMAD3_HUMAN176181SpecificityAltered binding specificityCDK8/9 phosphorylates Mothers against decapentaplegic homolog 3 (SMAD3) at T179 and S208. Phosphorylation of T179 creates a binding site for the WW domain of Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1), while phosphorylation of S208 primes SMAD3 for phosphorylation of S204 by Glycogen synthase kinase-3 beta (GSK3B). The pS204-pS208 forms a binding site for the third WW domain of E3 ubiquitin-protein ligase NEDD4-like (NEDD4L), whose second WW domain will displace the WW domain of PIN1 at the pT179-PY box site of SMAD3. This regulation couples SMAD3 activation to SMAD3 destruction in an ordered fashion. See also switch details and switch details.
details
Inferred

Cyclin-dependent kinase 9 - CDK9 -  Homo sapiens
DOC_WW_Pin1_4 P53_HUMAN312317BinaryPhysicochemical compatibilityPhosphorylation of S315 in the Pin1-binding motif of Cellular tumor antigen p53 (TP53) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 SMAD3_HUMAN176181BinaryPhysicochemical compatibilityPhosphorylation of T179 in the Pin1-binding motif of Mothers against decapentaplegic homolog 3 (SMAD3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 SMAD3_HUMAN205210BinaryPhysicochemical compatibilityPhosphorylation of S208 in the Pin1-binding motif of Mothers against decapentaplegic homolog 3 (SMAD3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 SMAD3_HUMAN210215BinaryPhysicochemical compatibilityPhosphorylation of S213 in the Pin1-binding motif of Mothers against decapentaplegic homolog 3 (SMAD3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 SMAD3_HUMAN176181SpecificityAltered binding specificityCDK8/9 phosphorylates Mothers against decapentaplegic homolog 3 (SMAD3) at T179 and S208. Phosphorylation of T179 creates a binding site for the WW domain of Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1), while phosphorylation of S208 primes SMAD3 for phosphorylation of S204 by Glycogen synthase kinase-3 beta (GSK3B). The pS204-pS208 forms a binding site for the third WW domain of E3 ubiquitin-protein ligase NEDD4-like (NEDD4L), whose second WW domain will displace the WW domain of PIN1 at the pT179-PY box site of SMAD3. This regulation couples SMAD3 activation to SMAD3 destruction in an ordered fashion. See also switch details and switch details.
details
Inferred

Glycogen synthase kinase-3 alpha - GSK3A -  Homo sapiens
DOC_WW_Pin1_4 MYC_HUMAN5560BinaryPhysicochemical compatibilityPhosphorylation of T58 in the Pin1-binding motif of Myc proto-oncogene protein (MYC) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 MYC_HUMAN5560BinaryPhysicochemical compatibilityPhosphorylation of T58 in the Pin1-binding motif of Myc proto-oncogene protein (MYC) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred

Glycogen synthase kinase-3 beta - GSK3B -  Homo sapiens
DOC_WW_Pin1_4 MYC_HUMAN5560BinaryPhysicochemical compatibilityPhosphorylation of T58 in the Pin1-binding motif of Myc proto-oncogene protein (MYC) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 MYC_HUMAN5560BinaryPhysicochemical compatibilityPhosphorylation of T58 in the Pin1-binding motif of Myc proto-oncogene protein (MYC) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred

Glycogen synthase kinase-3 beta - GSK3B -  Rattus norvegicus
DOC_WW_Pin1_4 MYC_HUMAN5560BinaryPhysicochemical compatibilityPhosphorylation of T58 in the Pin1-binding motif of Myc proto-oncogene protein (MYC) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred

Interleukin-1 receptor-associated kinase 1 - IRAK1 -  Homo sapiens
DOC_WW_Pin1_4 STAT3_HUMAN724729BinaryPhysicochemical compatibilityPhosphorylation of S727 in the Pin1-binding motif of Signal transducer and activator of transcription 3 (STAT3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 STAT3_HUMAN724729BinaryPhysicochemical compatibilityPhosphorylation of S727 in the Pin1-binding motif of Signal transducer and activator of transcription 3 (STAT3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred

Interleukin-1 receptor-associated kinase 4 - IRAK4 -  Homo sapiens
DOC_WW_Pin1_4 NCF1_HUMAN342347BinaryPhysicochemical compatibilityPhosphorylation of S345 in the Pin1-binding motif of Neutrophil cytosol factor 1 (NCF1) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred

Maternal embryonic leucine zipper kinase - MELK -  Mus musculus
DOC_WW_Pin1_4 SMAD3_HUMAN201206BinaryPhysicochemical compatibilityPhosphorylation of S204 in the Pin1-binding motif of Mothers against decapentaplegic homolog 3 (SMAD3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred

Mitogen-activated protein kinase 1 - MAPK1 -  Homo sapiens
DOC_WW_Pin1_4 MYC_HUMAN5560BinaryPhysicochemical compatibilityPhosphorylation of T58 in the Pin1-binding motif of Myc proto-oncogene protein (MYC) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 NCF1_HUMAN342347BinaryPhysicochemical compatibilityPhosphorylation of S345 in the Pin1-binding motif of Neutrophil cytosol factor 1 (NCF1) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 NR4A1_HUMAN428433BinaryPhysicochemical compatibilityPhosphorylation of S431 in the Pin1-binding motif of Nuclear receptor subfamily 4 group A member 1 (NR4A1) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 CDN1B_HUMAN184189BinaryPhysicochemical compatibilityPhosphorylation of T187 in the Pin1-binding motif of Cyclin-dependent kinase inhibitor 1B (CDKN1B) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 SMAD3_HUMAN176181BinaryPhysicochemical compatibilityPhosphorylation of T179 in the Pin1-binding motif of Mothers against decapentaplegic homolog 3 (SMAD3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 SMAD3_HUMAN176181BinaryPhysicochemical compatibilityPhosphorylation of T179 in the Pin1-binding motif of Mothers against decapentaplegic homolog 3 (SMAD3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 SMAD3_HUMAN176181BinaryPhysicochemical compatibilityPhosphorylation of T179 in the Pin1-binding motif of Mothers against decapentaplegic homolog 3 (SMAD3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 SMAD3_HUMAN201206BinaryPhysicochemical compatibilityPhosphorylation of S204 in the Pin1-binding motif of Mothers against decapentaplegic homolog 3 (SMAD3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 SMAD3_HUMAN201206BinaryPhysicochemical compatibilityPhosphorylation of S204 in the Pin1-binding motif of Mothers against decapentaplegic homolog 3 (SMAD3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 SMAD3_HUMAN201206BinaryPhysicochemical compatibilityPhosphorylation of S204 in the Pin1-binding motif of Mothers against decapentaplegic homolog 3 (SMAD3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 SMAD3_HUMAN201206BinaryPhysicochemical compatibilityPhosphorylation of S204 in the Pin1-binding motif of Mothers against decapentaplegic homolog 3 (SMAD3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 SMAD3_HUMAN205210BinaryPhysicochemical compatibilityPhosphorylation of S208 in the Pin1-binding motif of Mothers against decapentaplegic homolog 3 (SMAD3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 SMAD3_HUMAN205210BinaryPhysicochemical compatibilityPhosphorylation of S208 in the Pin1-binding motif of Mothers against decapentaplegic homolog 3 (SMAD3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 SMAD3_HUMAN205210BinaryPhysicochemical compatibilityPhosphorylation of S208 in the Pin1-binding motif of Mothers against decapentaplegic homolog 3 (SMAD3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 SMAD3_HUMAN205210BinaryPhysicochemical compatibilityPhosphorylation of S208 in the Pin1-binding motif of Mothers against decapentaplegic homolog 3 (SMAD3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 SMAD3_HUMAN210215BinaryPhysicochemical compatibilityPhosphorylation of S213 in the Pin1-binding motif of Mothers against decapentaplegic homolog 3 (SMAD3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 SMAD3_HUMAN210215BinaryPhysicochemical compatibilityPhosphorylation of S213 in the Pin1-binding motif of Mothers against decapentaplegic homolog 3 (SMAD3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 SMAD3_HUMAN176181SpecificityAltered binding specificityCDK8/9 phosphorylates Mothers against decapentaplegic homolog 3 (SMAD3) at T179 and S208. Phosphorylation of T179 creates a binding site for the WW domain of Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1), while phosphorylation of S208 primes SMAD3 for phosphorylation of S204 by Glycogen synthase kinase-3 beta (GSK3B). The pS204-pS208 forms a binding site for the third WW domain of E3 ubiquitin-protein ligase NEDD4-like (NEDD4L), whose second WW domain will displace the WW domain of PIN1 at the pT179-PY box site of SMAD3. This regulation couples SMAD3 activation to SMAD3 destruction in an ordered fashion. See also switch details and switch details.
details
Inferred
DOC_WW_Pin1_4 SMAD3_HUMAN176181SpecificityAltered binding specificityCDK8/9 phosphorylates Mothers against decapentaplegic homolog 3 (SMAD3) at T179 and S208. Phosphorylation of T179 creates a binding site for the WW domain of Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1), while phosphorylation of S208 primes SMAD3 for phosphorylation of S204 by Glycogen synthase kinase-3 beta (GSK3B). The pS204-pS208 forms a binding site for the third WW domain of E3 ubiquitin-protein ligase NEDD4-like (NEDD4L), whose second WW domain will displace the WW domain of PIN1 at the pT179-PY box site of SMAD3. This regulation couples SMAD3 activation to SMAD3 destruction in an ordered fashion. See also switch details and switch details.
details
Inferred
DOC_WW_Pin1_4 SMAD3_HUMAN176181SpecificityAltered binding specificityCDK8/9 phosphorylates Mothers against decapentaplegic homolog 3 (SMAD3) at T179 and S208. Phosphorylation of T179 creates a binding site for the WW domain of Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1), while phosphorylation of S208 primes SMAD3 for phosphorylation of S204 by Glycogen synthase kinase-3 beta (GSK3B). The pS204-pS208 forms a binding site for the third WW domain of E3 ubiquitin-protein ligase NEDD4-like (NEDD4L), whose second WW domain will displace the WW domain of PIN1 at the pT179-PY box site of SMAD3. This regulation couples SMAD3 activation to SMAD3 destruction in an ordered fashion. See also switch details and switch details.
details
Inferred

Mitogen-activated protein kinase 10 - MAPK10 -  Homo sapiens
DOC_WW_Pin1_4 MYC_HUMAN5560BinaryPhysicochemical compatibilityPhosphorylation of T58 in the Pin1-binding motif of Myc proto-oncogene protein (MYC) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred

Mitogen-activated protein kinase 14 - MAPK14 -  Homo sapiens
DOC_WW_Pin1_4 NCF1_HUMAN342347BinaryPhysicochemical compatibilityPhosphorylation of S345 in the Pin1-binding motif of Neutrophil cytosol factor 1 (NCF1) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 NCF1_HUMAN342347BinaryPhysicochemical compatibilityPhosphorylation of S345 in the Pin1-binding motif of Neutrophil cytosol factor 1 (NCF1) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 STAT3_HUMAN724729BinaryPhysicochemical compatibilityPhosphorylation of S727 in the Pin1-binding motif of Signal transducer and activator of transcription 3 (STAT3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred

Mitogen-activated protein kinase 15 - MAPK15 -  Homo sapiens
DOC_WW_Pin1_4 JUN_HUMAN6065BinaryPhysicochemical compatibilityPhosphorylation of S63 in the Pin1-binding motif of Transcription factor AP-1 (JUN) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 JUN_HUMAN7075BinaryPhysicochemical compatibilityPhosphorylation of S73 in the Pin1-binding motif of Transcription factor AP-1 (JUN) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred

Mitogen-activated protein kinase 3 - MAPK3 -  Homo sapiens
DOC_WW_Pin1_4 NCF1_HUMAN342347BinaryPhysicochemical compatibilityPhosphorylation of S345 in the Pin1-binding motif of Neutrophil cytosol factor 1 (NCF1) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 NCF1_HUMAN342347BinaryPhysicochemical compatibilityPhosphorylation of S345 in the Pin1-binding motif of Neutrophil cytosol factor 1 (NCF1) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 CDN1B_HUMAN184189BinaryPhysicochemical compatibilityPhosphorylation of T187 in the Pin1-binding motif of Cyclin-dependent kinase inhibitor 1B (CDKN1B) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 ST4A1_HUMAN813BinaryPhysicochemical compatibilityPhosphorylation of T11 in the Pin1-binding motif of Sulfotransferase 4A1 (SULT4A1) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred

Mitogen-activated protein kinase 7 - MAPK7 -  Homo sapiens
DOC_WW_Pin1_4 PML_HUMAN400405BinaryPhysicochemical compatibilityPhosphorylation of S403 in the Pin1-binding motif of Protein PML (PML) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred

Mitogen-activated protein kinase 8 - MAPK8 -  Homo sapiens
DOC_WW_Pin1_4 P53_HUMAN7883BinaryPhysicochemical compatibilityPhosphorylation of T81 in the Pin1-binding motif of Cellular tumor antigen p53 (TP53) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 JUN_HUMAN6065BinaryPhysicochemical compatibilityPhosphorylation of S63 in the Pin1-binding motif of Transcription factor AP-1 (JUN) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 JUN_HUMAN6065BinaryPhysicochemical compatibilityPhosphorylation of S63 in the Pin1-binding motif of Transcription factor AP-1 (JUN) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 JUN_HUMAN6065BinaryPhysicochemical compatibilityPhosphorylation of S63 in the Pin1-binding motif of Transcription factor AP-1 (JUN) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 JUN_HUMAN7075BinaryPhysicochemical compatibilityPhosphorylation of S73 in the Pin1-binding motif of Transcription factor AP-1 (JUN) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 JUN_HUMAN7075BinaryPhysicochemical compatibilityPhosphorylation of S73 in the Pin1-binding motif of Transcription factor AP-1 (JUN) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 NR4A1_HUMAN9297BinaryPhysicochemical compatibilityPhosphorylation of S95 in the Pin1-binding motif of Nuclear receptor subfamily 4 group A member 1 (NR4A1) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 STAT3_HUMAN724729BinaryPhysicochemical compatibilityPhosphorylation of S727 in the Pin1-binding motif of Signal transducer and activator of transcription 3 (STAT3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred

Mitogen-activated protein kinase 9 - MAPK9 -  Homo sapiens
DOC_WW_Pin1_4 JUN_HUMAN6065BinaryPhysicochemical compatibilityPhosphorylation of S63 in the Pin1-binding motif of Transcription factor AP-1 (JUN) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 JUN_HUMAN6065BinaryPhysicochemical compatibilityPhosphorylation of S63 in the Pin1-binding motif of Transcription factor AP-1 (JUN) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 JUN_HUMAN7075BinaryPhysicochemical compatibilityPhosphorylation of S73 in the Pin1-binding motif of Transcription factor AP-1 (JUN) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred

Mitogen-activated protein kinase 9 - MAPK9 -  Homo sapiens
DOC_WW_Pin1_4 STAT3_HUMAN724729BinaryPhysicochemical compatibilityPhosphorylation of S727 in the Pin1-binding motif of Signal transducer and activator of transcription 3 (STAT3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred

Protein kinase C delta type - PRKCD -  Homo sapiens
DOC_WW_Pin1_4 STAT3_HUMAN724729BinaryPhysicochemical compatibilityPhosphorylation of S727 in the Pin1-binding motif of Signal transducer and activator of transcription 3 (STAT3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 STAT3_HUMAN724729BinaryPhysicochemical compatibilityPhosphorylation of S727 in the Pin1-binding motif of Signal transducer and activator of transcription 3 (STAT3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred

Protein kinase C epsilon type - PRKCE -  Homo sapiens
DOC_WW_Pin1_4 STAT3_HUMAN724729BinaryPhysicochemical compatibilityPhosphorylation of S727 in the Pin1-binding motif of Signal transducer and activator of transcription 3 (STAT3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred

Ribosomal protein S6 kinase alpha-3 - RPS6KA3 -  Homo sapiens
DOC_WW_Pin1_4 STAT3_HUMAN724729BinaryPhysicochemical compatibilityPhosphorylation of S727 in the Pin1-binding motif of Signal transducer and activator of transcription 3 (STAT3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred

Serine/threonine-protein kinase D1 - PRKD1 -  Homo sapiens
DOC_WW_Pin1_4 JUN_HUMAN6065BinaryPhysicochemical compatibilityPhosphorylation of S63 in the Pin1-binding motif of Transcription factor AP-1 (JUN) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred

Serine/threonine-protein kinase PLK3 - PLK3 -  Homo sapiens
DOC_WW_Pin1_4 JUN_HUMAN6065BinaryPhysicochemical compatibilityPhosphorylation of S63 in the Pin1-binding motif of Transcription factor AP-1 (JUN) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 JUN_HUMAN7075BinaryPhysicochemical compatibilityPhosphorylation of S73 in the Pin1-binding motif of Transcription factor AP-1 (JUN) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred

Serine/threonine-protein kinase VRK1 - VRK1 -  Homo sapiens
DOC_WW_Pin1_4 JUN_HUMAN6065BinaryPhysicochemical compatibilityPhosphorylation of S63 in the Pin1-binding motif of Transcription factor AP-1 (JUN) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 JUN_HUMAN6065BinaryPhysicochemical compatibilityPhosphorylation of S63 in the Pin1-binding motif of Transcription factor AP-1 (JUN) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 JUN_HUMAN7075BinaryPhysicochemical compatibilityPhosphorylation of S73 in the Pin1-binding motif of Transcription factor AP-1 (JUN) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 JUN_HUMAN7075BinaryPhysicochemical compatibilityPhosphorylation of S73 in the Pin1-binding motif of Transcription factor AP-1 (JUN) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred

Serine/threonine-protein kinase mTOR - MTOR -  Homo sapiens
DOC_WW_Pin1_4 AKT1_HUMAN447452BinaryPhysicochemical compatibilityPhosphorylation of T450 in the Pin1-binding motif of RAC-alpha serine/threonine-protein kinase (AKT1) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred

Serine/threonine-protein kinase mTOR - MTOR -  Mus musculus
DOC_WW_Pin1_4 STAT3_HUMAN724729BinaryPhysicochemical compatibilityPhosphorylation of S727 in the Pin1-binding motif of Signal transducer and activator of transcription 3 (STAT3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
           
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