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Group by :Switch typeMotif classProteinEnzymePathway            Group Index    Colouring Info              Filtered: UNIPROT:P29353 (16 hits) x
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x  Coloured by switch type.
  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
  Uncategorised  Rheostatic  Allostery  Avidity-sensing
  Physicochemical compatibility  Pre-translational  Competition

x  Index
High affinity nerve growth factor receptorInsulin receptorIntegrin beta-3
Integrin beta-4Interleukin-2 receptor subunit betaInterleukin-4 receptor subunit alpha
Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1Prolow-density lipoprotein receptor-related protein 1Receptor tyrosine-protein kinase erbB-3
SHC-transforming protein 1


MotifStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

High affinity nerve growth factor receptor - NTRK1 -  Homo sapiens
LIG_PTB_Phospho_1490496BinaryPhysicochemical compatibilityPhosphorylation of Y496 in the PTB-binding motif of High affinity nerve growth factor receptor (NTRK1) induces binding to the SHC-transforming protein 1 (SHC1) protein.
details
LIG_SH2_IIB782796BinaryPhysicochemical compatibilityPhosphorylation of Y791 in the SH2-binding motif of High affinity nerve growth factor receptor (NTRK1) induces binding to the SHC-transforming protein 1 (SHC1) protein.
details

Insulin receptor - INSR -  Homo sapiens
LIG_PTB_Phospho_1993999BinaryPhysicochemical compatibilityPhosphorylation of Y999 in the PTB-binding motif of Insulin receptor (INSR) induces binding to the SHC-transforming protein 1 (SHC1) protein.
details

Integrin beta-3 - ITGB3 -  Homo sapiens
LIG_PTB_Phospho_1779785BinaryPhysicochemical compatibilityPhosphorylation of Y785 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to the SHC-transforming protein 1 (SHC1) protein.
details
LIG_PTB_Phospho_1779785BinaryPhysicochemical compatibilityPhosphorylation of T779 in the PTB-binding motif of Integrin beta-3 (ITGB3) inhibits its interaction with SHC-transforming protein 1 (SHC1).
details
LIG_PTB_Phospho_1779785CumulativeRheostaticWhile phosphorylation of Y785 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to SHC-transforming protein 1 (SHC1), additional phosphorylation of Y773 further increases the strength of the interaction.
details
LIG_PTB_Phospho_1779785SpecificityAltered binding specificityPhosphorylation of Integrin beta-3 (ITGB3) at Y785 switches the specificity of integrin from Kindlin-2 (Fermitin family homolog 2 (FERMT2)) to the adaptor protein SHC-transforming protein 1 (SHC1).
details

Integrin beta-4 - ITGB4 -  Homo sapiens
LIG_PTB_Phospho_115901596BinaryPhysicochemical compatibilityPhosphorylation of Y1596 in the PTB-binding motif of Integrin beta-4 (ITGB4) induces binding to the SHC-transforming protein 1 (SHC1) protein.
details

Interleukin-2 receptor subunit beta - IL2RB -  Homo sapiens
LIG_PTB_Phospho_1358364BinaryPhysicochemical compatibilityPhosphorylation of Y364 in the PTB-binding motif of Interleukin-2 receptor subunit beta (IL2RB) induces binding to the SHC-transforming protein 1 (SHC1) protein.
details
LIG_SH2_IIB361370BinaryPhysicochemical compatibilityPhosphorylation of Y364 in the SH2-binding motif of Interleukin-2 receptor subunit beta (IL2RB) induces binding to the SHC-transforming protein 1 (SHC1) protein.
details

Interleukin-4 receptor subunit alpha - IL4R -  Homo sapiens
LIG_SH2_IIB706721BinaryPhysicochemical compatibilityPhosphorylation of Y713 in the SH2-binding motif of Interleukin-4 receptor subunit alpha (IL4R) induces binding to the SHC-transforming protein 1 (SHC1) protein.
details

Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 - INPP5D -  Homo sapiens
LIG_PTB_Phospho_110161022BinaryPhysicochemical compatibilityPhosphorylation of Y1022 in the PTB-binding motif of Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (INPP5D) induces binding to the SHC-transforming protein 1 (SHC1) protein.
details
LIG_PTB_Phospho_1909915BinaryPhysicochemical compatibilityPhosphorylation of Y915 in the PTB-binding motif of Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (INPP5D) induces binding to the SHC-transforming protein 1 (SHC1) protein.
details

Prolow-density lipoprotein receptor-related protein 1 - LRP1 -  Homo sapiens
LIG_PTB_Phospho_145014507BinaryPhysicochemical compatibilityPhosphorylation of Y4507 in the PTB-binding motif of Prolow-density lipoprotein receptor-related protein 1 (LRP1) induces binding to the SHC-transforming protein 1 (SHC1) protein.
details

Receptor tyrosine-protein kinase erbB-3 - ERBB3 -  Homo sapiens
LIG_PTB_Phospho_113221328BinaryPhysicochemical compatibilityPhosphorylation of Y1328 in the PTB-binding motif of Receptor tyrosine-protein kinase erbB-3 (ERBB3) induces binding to the SHC-transforming protein 1 (SHC1) protein.
details

SHC-transforming protein 1 - SHC1 -  Homo sapiens
LIG_SH2_IC423435BinaryPhysicochemical compatibilityPhosphorylation of Y427 in the SH2-binding motif of SHC-transforming protein 1 (SHC1) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.
details
           
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