switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Group Index Colouring Info Filtered: UNIPROT:Q9Y297 (18 hits) x

x Coloured by switch type.

Domain hiding	Altered binding specificity	Motif hiding	Composite binding site formation
Uncategorised	Rheostatic	Allostery	Avidity-sensing
Physicochemical compatibility	Pre-translational	Competition

x Index

Bcl-2-like protein 11	Catenin beta-1	Claspin
Cyclic AMP-dependent transcription factor ATF-4	Disks large homolog 1	F-box only protein 5
FYVE, RhoGEF and PH domain-containing protein 1	FYVE, RhoGEF and PH domain-containing protein 3	NF-kappa-B inhibitor alpha
NF-kappa-B inhibitor beta	NF-kappa-B inhibitor epsilon	Nuclear factor NF-kappa-B p105 subunit
Programmed cell death protein 4	Protein Vpu (Human)	Protein aurora borealis
RE1-silencing transcription factor	Yorkie homolog	Zinc finger protein SNAI1

Motif

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Information

Bcl-2-like protein 11 - BCL2L11 - Homo sapiens
DEG_SCF_TRCP1_2	93	98	Binary	Pre‑translational	Alternative splicing removes the extended SCF-TrCP degron motif of Bcl-2-like protein 11 (BCL2L11), abrogating binding to F-box/WD repeat-containing protein 1A (BTRC). Upon mitogen survival signals, RPS6KA1 and RPS6KA2 kinases are up-regulated and rapidly phosphorylate the three serines of Isoform Bim(EL) of Bcl-2-like protein 11 (BCL2L11). This facilitates the binding of betaTrCP and subsequent ubiquitination and degradation of Isoform Bim(EL) of Bcl-2-like protein 11 (BCL2L11).	details
Catenin beta-1 - CTNNB1 - Homo sapiens
DEG_SCF_TRCP1_1	32	37	Specificity	Altered binding specificity	Phosphorylation of Catenin beta-1 (CTNNB1) at T41 generates a docking site for Glycogen synthase kinase-3 beta (GSK3B), which then phosphorylates S37, thereby generating a new docking site for GSK3B. Subsequent phosphorylation of S33 by GSK3B switches the specificity of CTNNB1 to the F-box/WD repeat-containing protein 1A (BTRC), which recruits CTNNB1 to the SCF ubiquitin ligase complex.	details
Claspin - CLSPN - Homo sapiens
DEG_SCF_TRCP1_1	29	34	Binary	Physicochemical compatibility	Dual phosphorylation of S30 and S34 in the TrCP1-binding motif of Claspin (CLSPN) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.	details
Cyclic AMP-dependent transcription factor ATF-4 - ATF4 - Homo sapiens
DEG_SCF_TRCP1_1	218	224	Binary	Physicochemical compatibility	Dual phosphorylation of S219 and S224 in the TrCP1-binding motif of Cyclic AMP-dependent transcription factor ATF-4 (ATF4) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.	details
Disks large homolog 1 - DLG1 - Homo sapiens
DEG_SCF_TRCP1_1	597	602	Binary	Physicochemical compatibility	Dual phosphorylation of S598 and S602 in the TrCP1-binding motif of Disks large homolog 1 (DLG1) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.	details
F-box only protein 5 - FBXO5 - Homo sapiens
DEG_SCF_TRCP1_1	144	149	Binary	Physicochemical compatibility	Dual phosphorylation of S145 and S149 in the TrCP1-binding motif of F-box only protein 5 (FBXO5) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.	details
FYVE, RhoGEF and PH domain-containing protein 1 - FGD1 - Homo sapiens
DEG_SCF_TRCP1_1	282	287	Specificity	Altered binding specificity	Phosphorylation of FYVE, RhoGEF and PH domain-containing protein 1 (FGD1), a GEF for CDC42 small effector protein 2 (CDC42SE2), by Glycogen synthase kinase-3 beta (GSK3B) targets FGD1 to the SCF ubiquitin ligase complex, F-box/WD repeat-containing protein 1A (BTRC), which marks FGD1 for degradation.	details
FYVE, RhoGEF and PH domain-containing protein 3 - FGD3 - Homo sapiens
DEG_SCF_TRCP1_1	75	80	Specificity	Altered binding specificity	Phosphorylation of FYVE, RhoGEF and PH domain-containing protein 3 (FGD3), a GEF for CDC42 small effector protein 2 (CDC42SE2), by Glycogen synthase kinase-3 beta (GSK3B) targets FGD3 to the SCF ubiquitin ligase complex, F-box/WD repeat-containing protein 1A (BTRC), which marks FGD3 for degradation.	details
NF-kappa-B inhibitor alpha - NFKBIA - Homo sapiens
DEG_SCF_TRCP1_1	31	36	Binary	Physicochemical compatibility	Dual phosphorylation of S32 and S36 in the TrCP1-binding motif of NF-kappa-B inhibitor alpha (NFKBIA) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.	details
NF-kappa-B inhibitor beta - NFKBIB - Homo sapiens
DEG_SCF_TRCP1_1	18	23	Binary	Physicochemical compatibility	Dual phosphorylation of S19 and S23 in the TrCP1-binding motif of NF-kappa-B inhibitor beta (NFKBIB) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.	details
NF-kappa-B inhibitor epsilon - NFKBIE - Homo sapiens
DEG_SCF_TRCP1_1	156	161	Binary	Physicochemical compatibility	Dual phosphorylation of S157 and S161 in the TrCP1-binding motif of NF-kappa-B inhibitor epsilon (NFKBIE) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.	details
Nuclear factor NF-kappa-B p105 subunit - NFKB1 - Homo sapiens
DEG_SCF_TRCP1_1	926	932	Binary	Physicochemical compatibility	Dual phosphorylation of S927 and S932 in the TrCP1-binding motif of Nuclear factor NF-kappa-B p105 subunit (NFKB1) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.	details
Programmed cell death protein 4 - PDCD4 - Homo sapiens
DEG_SCF_TRCP1_1	70	76	Binary	Physicochemical compatibility	Dual phosphorylation of S71 and S76 in the TrCP1-binding motif of Programmed cell death protein 4 (PDCD4) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.	details
Protein Vpu - vpu - Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)
DEG_SCF_TRCP1_1	51	56	Binary	Physicochemical compatibility	Dual phosphorylation of S52 and S56 in the TrCP1-binding motif of Protein Vpu (vpu) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.	details
Protein aurora borealis - BORA - Homo sapiens
DEG_SCF_TRCP1_1	496	501	Binary	Physicochemical compatibility	Dual phosphorylation of S497 and T501 in the TrCP1-binding motif of Protein aurora borealis (BORA) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.	details
RE1-silencing transcription factor - REST - Homo sapiens
DEG_SCF_TRCP1_2	1008	1013	Binary	Pre‑translational	Alternative splicing removes the beta-TrCP-binding degron of RE1-silencing transcription factor (REST), abrogating binding to F-box/WD repeat-containing protein 1A (BTRC), and therefore altering the half-life of the variant. Up-regulation of the protein isoform without the degron has been linked to cancer.	details
Yorkie homolog - YAP1 - Homo sapiens
DEG_SCF_TRCP1_2	383	387	Specificity	Altered binding specificity	Phosphorylation of Yorkie homolog (YAP1) at S381 by Serine/threonine-protein kinase LATS1 (LATS1) (a key regulator of the Hippo Pathway) primes the sequence for phosphorylation by Casein kinase I isoform epsilon (CSNK1E) at S384 and S387. This targets YAP1 to the SCF ubiqutin ligase complex, F-box/WD repeat-containing protein 1A (BTRC), which marks is YAP1 for subsequent degradation by the proteasomal system. N.B. Serine/threonine-protein kinase LATS2 (LATS2) can replace LATS1 and Casein kinase I isoform delta (CSNK1D) can replace CSNK1E	details
Zinc finger protein SNAI1 - SNAI1 - Homo sapiens
DEG_SCF_TRCP1_1	95	100	Specificity	Altered binding specificity	Phosphorylation of Zinc finger protein SNAI1 (SNAI1) at S100 generates a docking site for Glycogen synthase kinase-3 beta (GSK3B). Subsequent phosphorylation of S96 by GSK3B targets Zinc finger protein SNAI1 (SNAI1) to the SCF ubiquitin ligase complexes F-box/WD repeat-containing protein 1A (BTRC), which marks it for degradation.	details