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Filtered:
PFAM:PF00017 (49 hits)
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Pathway evidence source
Curated
inferred
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Index
B cell receptor signaling pathway
Calcium signaling pathway
DAP12 interactions
ErbB signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Growth hormone receptor signaling
Jak-STAT signaling pathway
MAPK signaling pathway
NF-kappa B signaling pathway
Natural killer cell mediated cytotoxicity
Osteoclast differentiation
PI3K-Akt signaling pathway
T cell receptor signaling pathway
TCR signaling
Motif
Protein
Start
End
Switch Type
Switch Subtype
Switch description
Information
Evidence
(
Reactome - 2676022
)
LIG_TYR_ITAM
CD79A_MOUSE
179
196
Avidity‑sensing
Phosphorylation of Y182 and Y193 in the ITAM motif of
B-cell antigen receptor complex-associated protein alpha chain (Cd79a)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (Syk)
. Maximal Syk activation requires both Syk SH2 domains and phosphorylation of both ITAM tyrosine residues.
details
Curated
LIG_TYR_ITAM
CD79A_MOUSE
179
196
Avidity‑sensing
Phosphorylation of Y182 and Y193 in the ITAM motif of
B-cell antigen receptor complex-associated protein alpha chain (Cd79a)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (Syk)
. Maximal Syk activation requires both Syk SH2 domains and phosphorylation of both ITAM tyrosine residues.
details
Curated
B cell receptor signaling pathway
(
KEGG - mmu04662
)
LIG_TYR_ITAM
CD79A_MOUSE
179
196
Avidity‑sensing
Phosphorylation of Y182 and Y193 in the ITAM motif of
B-cell antigen receptor complex-associated protein alpha chain (Cd79a)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (Syk)
. Maximal Syk activation requires both Syk SH2 domains and phosphorylation of both ITAM tyrosine residues.
details
Curated
LIG_TYR_ITAM
CD79A_MOUSE
179
196
Avidity‑sensing
Phosphorylation of Y182 and Y193 in the ITAM motif of
B-cell antigen receptor complex-associated protein alpha chain (Cd79a)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (Syk)
. Maximal Syk activation requires both Syk SH2 domains and phosphorylation of both ITAM tyrosine residues.
details
Curated
Calcium signaling pathway
(
KEGG - hsa04020
)
LIG_SH2_SRC
EGFR_HUMAN
1016
1019
Binary
Physicochemical compatibility
Phosphorylation of Y1016 in the SH2-binding motif of
Epidermal growth factor receptor (EGFR)
induces binding to
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1)
.
details
Curated
DAP12 interactions
(
Reactome - 2172127
)
LIG_SH2_STAT5
LAT_HUMAN
161
164
Binary
Physicochemical compatibility
Phosphorylation of Y161 in the SH2-binding motif of
Linker for activation of T-cells family member 1 (LAT)
induces binding to the
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1)
protein.
details
Curated
ErbB signaling pathway
(
KEGG - hsa04012
)
LIG_SH2_IC
EGFR_HUMAN
1092
1100
Binary
Physicochemical compatibility
Phosphorylation of Y1092 in the SH2-binding motif of
Epidermal growth factor receptor (EGFR)
induces binding to the
Growth factor receptor-bound protein 2 (GRB2)
protein.
details
Curated
LIG_SH2_III
STA5A_HUMAN
686
702
Binary
Physicochemical compatibility
Phosphorylation of Y694 in the SH2-binding motif of
Signal transducer and activator of transcription 5A (STAT5A)
induces binding to the
Signal transducer and activator of transcription 5B (STAT5B)
protein.
details
Curated
LIG_SH2_SRC
EGFR_HUMAN
1016
1019
Binary
Physicochemical compatibility
Phosphorylation of Y1016 in the SH2-binding motif of
Epidermal growth factor receptor (EGFR)
induces binding to
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1)
.
details
Curated
LIG_SH2_SRC
EGFR_HUMAN
1125
1128
Binary
Physicochemical compatibility
Phosphorylation of Y1125 in the SH2-binding motif of
Epidermal growth factor receptor (EGFR)
induces binding to
Adapter molecule crk (CRK)
.
details
Curated
LIG_SH2_SRC
EGFR_HUMAN
1016
1019
Binary
Physicochemical compatibility
Phosphorylation of Y1016 in the SH2-binding motif of
Epidermal growth factor receptor (EGFR)
induces binding to
Cytoplasmic protein NCK1 (NCK1)
.
details
Curated
LIG_SH2_GRB2
ERBB3_HUMAN
1262
1265
Binary
Physicochemical compatibility
Phosphorylation of Y1262 in the SH2-binding motif of
Receptor tyrosine-protein kinase erbB-3 (ERBB3)
induces binding to
Growth factor receptor-bound protein 2 (GRB2)
.
details
Curated
LIG_SH2_SRC
FAK1_HUMAN
397
400
Binary
Physicochemical compatibility
Phosphorylation of Y397 in the SH2-binding motif of
Focal adhesion kinase 1 (PTK2)
induces binding to
Neuronal proto-oncogene tyrosine-protein kinase Src (Src)
.
details
Curated
LIG_SH2_STAT5
GAB1_HUMAN
472
475
Binary
Physicochemical compatibility
Phosphorylation of Y472 in the SH2-binding motif of
GRB2-associated-binding protein 1 (GAB1)
induces binding to
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)
.
details
Curated
LIG_SH2_STAT5
GAB1_HUMAN
447
450
Binary
Physicochemical compatibility
Phosphorylation of Y447 in the SH2-binding motif of
GRB2-associated-binding protein 1 (GAB1)
induces binding to
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)
.
details
Curated
Fc epsilon RI signaling pathway
(
KEGG - hsa04664
)
LIG_TYR_ITAM
FCERG_HUMAN
62
79
Avidity‑sensing
Phosphorylation of Y65 and Y76 in the ITAM motif of
High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (SYK)
.
details
Curated
LIG_TYR_ITAM
FCERG_HUMAN
62
79
Avidity‑sensing
Phosphorylation of Y65 and Y76 in the ITAM motif of
High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (SYK)
.
details
Curated
LIG_SH2_IA
FCERG_HUMAN
75
79
Binary
Physicochemical compatibility
Phosphorylation of Y76 in the SH2-binding motif of
High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G)
induces binding to the
Tyrosine-protein kinase SYK (SYK)
protein.
details
Curated
Fc gamma R-mediated phagocytosis
(
KEGG - hsa04666
)
LIG_TYR_ITAM
FCG2A_HUMAN
285
307
Avidity‑sensing
Phosphorylation of Y288 and Y304 in the ITAM motif of
Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (SYK)
.
details
Curated
LIG_TYR_ITAM
FCG2A_HUMAN
285
307
Avidity‑sensing
Phosphorylation of Y288 and Y304 in the ITAM motif of
Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (SYK)
.
details
Curated
Growth hormone receptor signaling
(
Reactome - 982772
)
LIG_SH2_III
STA5A_HUMAN
686
702
Binary
Physicochemical compatibility
Phosphorylation of Y694 in the SH2-binding motif of
Signal transducer and activator of transcription 5A (STAT5A)
induces binding to the
Signal transducer and activator of transcription 5B (STAT5B)
protein.
details
Curated
Jak-STAT signaling pathway
(
KEGG - hsa04630
)
LIG_SH2_III
STA5A_HUMAN
686
702
Binary
Physicochemical compatibility
Phosphorylation of Y694 in the SH2-binding motif of
Signal transducer and activator of transcription 5A (STAT5A)
induces binding to the
Signal transducer and activator of transcription 5B (STAT5B)
protein.
details
Curated
MAPK signaling pathway
(
KEGG - hsa04010
)
LIG_SH2_IC
EGFR_HUMAN
1092
1100
Binary
Physicochemical compatibility
Phosphorylation of Y1092 in the SH2-binding motif of
Epidermal growth factor receptor (EGFR)
induces binding to the
Growth factor receptor-bound protein 2 (GRB2)
protein.
details
Curated
NF-kappa B signaling pathway
(
KEGG - hsa04064
)
LIG_SH2_STAT5
LAT_HUMAN
161
164
Binary
Physicochemical compatibility
Phosphorylation of Y161 in the SH2-binding motif of
Linker for activation of T-cells family member 1 (LAT)
induces binding to the
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1)
protein.
details
Curated
Natural killer cell mediated cytotoxicity
(
KEGG - hsa04650
)
LIG_SH2_STAT5
LAT_HUMAN
161
164
Binary
Physicochemical compatibility
Phosphorylation of Y161 in the SH2-binding motif of
Linker for activation of T-cells family member 1 (LAT)
induces binding to the
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1)
protein.
details
Curated
LIG_TYR_ITAM
FCERG_HUMAN
62
79
Avidity‑sensing
Phosphorylation of Y65 and Y76 in the ITAM motif of
High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (SYK)
.
details
Curated
LIG_TYR_ITAM
FCERG_HUMAN
62
79
Avidity‑sensing
Phosphorylation of Y65 and Y76 in the ITAM motif of
High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (SYK)
.
details
Curated
LIG_SH2_IA
FCERG_HUMAN
75
79
Binary
Physicochemical compatibility
Phosphorylation of Y76 in the SH2-binding motif of
High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G)
induces binding to the
Tyrosine-protein kinase SYK (SYK)
protein.
details
Curated
Osteoclast differentiation
(
KEGG - hsa04380
)
LIG_TYR_ITAM
FCG2A_HUMAN
285
307
Avidity‑sensing
Phosphorylation of Y288 and Y304 in the ITAM motif of
Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (SYK)
.
details
Curated
LIG_TYR_ITAM
FCG2A_HUMAN
285
307
Avidity‑sensing
Phosphorylation of Y288 and Y304 in the ITAM motif of
Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase SYK (SYK)
.
details
Curated
PI3K-Akt signaling pathway
(
KEGG - hsa04151
)
LIG_SH2_IC
EGFR_HUMAN
1092
1100
Binary
Physicochemical compatibility
Phosphorylation of Y1092 in the SH2-binding motif of
Epidermal growth factor receptor (EGFR)
induces binding to the
Growth factor receptor-bound protein 2 (GRB2)
protein.
details
Curated
T cell receptor signaling pathway
(
KEGG - hsa04660
)
LIG_SH2_STAT5
LAT_HUMAN
161
164
Binary
Physicochemical compatibility
Phosphorylation of Y161 in the SH2-binding motif of
Linker for activation of T-cells family member 1 (LAT)
induces binding to the
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1)
protein.
details
Curated
LIG_TYR_ITAM
CD3Z_HUMAN
69
86
Avidity‑sensing
Phosphorylation of Y72 and Y83 in the ITAM motif of
T-cell surface glycoprotein CD3 zeta chain (CD247)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase ZAP-70 (ZAP70)
.
details
Curated
LIG_TYR_ITAM
CD3Z_HUMAN
69
86
Avidity‑sensing
Phosphorylation of Y72 and Y83 in the ITAM motif of
T-cell surface glycoprotein CD3 zeta chain (CD247)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase ZAP-70 (ZAP70)
.
details
Curated
LIG_TYR_ITAM
CD3Z_HUMAN
108
126
Avidity‑sensing
Phosphorylation of Y111 and Y123 in the ITAM motif of
T-cell surface glycoprotein CD3 zeta chain (CD247)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase ZAP-70 (ZAP70)
.
details
Curated
LIG_TYR_ITAM
CD3Z_HUMAN
108
126
Avidity‑sensing
Phosphorylation of Y111 and Y123 in the ITAM motif of
T-cell surface glycoprotein CD3 zeta chain (CD247)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase ZAP-70 (ZAP70)
.
details
Curated
LIG_TYR_ITAM
CD3Z_HUMAN
139
156
Avidity‑sensing
Phosphorylation of Y142 and Y153 in the ITAM motif of
T-cell surface glycoprotein CD3 zeta chain (CD247)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase ZAP-70 (ZAP70)
.
details
Curated
LIG_TYR_ITAM
CD3Z_HUMAN
139
156
Avidity‑sensing
Phosphorylation of Y142 and Y153 in the ITAM motif of
T-cell surface glycoprotein CD3 zeta chain (CD247)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase ZAP-70 (ZAP70)
.
details
Curated
LIG_TYR_ITAM
CD3G_HUMAN
157
174
Avidity‑sensing
Phosphorylation of Y160 and Y171 in the ITAM motif of
T-cell surface glycoprotein CD3 gamma chain (CD3G)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase ZAP-70 (ZAP70)
.
details
Curated
LIG_TYR_ITAM
CD3G_HUMAN
157
174
Avidity‑sensing
Phosphorylation of Y160 and Y171 in the ITAM motif of
T-cell surface glycoprotein CD3 gamma chain (CD3G)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase ZAP-70 (ZAP70)
.
details
Curated
TCR signaling
(
Reactome - 202403
)
LIG_SH2_STAT5
LAT_HUMAN
161
164
Binary
Physicochemical compatibility
Phosphorylation of Y161 in the SH2-binding motif of
Linker for activation of T-cells family member 1 (LAT)
induces binding to the
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1)
protein.
details
Curated
LIG_TYR_ITAM
CD3Z_HUMAN
69
86
Avidity‑sensing
Phosphorylation of Y72 and Y83 in the ITAM motif of
T-cell surface glycoprotein CD3 zeta chain (CD247)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase ZAP-70 (ZAP70)
.
details
Curated
LIG_TYR_ITAM
CD3Z_HUMAN
69
86
Avidity‑sensing
Phosphorylation of Y72 and Y83 in the ITAM motif of
T-cell surface glycoprotein CD3 zeta chain (CD247)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase ZAP-70 (ZAP70)
.
details
Curated
LIG_TYR_ITAM
CD3Z_HUMAN
108
126
Avidity‑sensing
Phosphorylation of Y111 and Y123 in the ITAM motif of
T-cell surface glycoprotein CD3 zeta chain (CD247)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase ZAP-70 (ZAP70)
.
details
Curated
LIG_TYR_ITAM
CD3Z_HUMAN
108
126
Avidity‑sensing
Phosphorylation of Y111 and Y123 in the ITAM motif of
T-cell surface glycoprotein CD3 zeta chain (CD247)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase ZAP-70 (ZAP70)
.
details
Curated
LIG_TYR_ITAM
CD3Z_HUMAN
139
156
Avidity‑sensing
Phosphorylation of Y142 and Y153 in the ITAM motif of
T-cell surface glycoprotein CD3 zeta chain (CD247)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase ZAP-70 (ZAP70)
.
details
Curated
LIG_TYR_ITAM
CD3Z_HUMAN
139
156
Avidity‑sensing
Phosphorylation of Y142 and Y153 in the ITAM motif of
T-cell surface glycoprotein CD3 zeta chain (CD247)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase ZAP-70 (ZAP70)
.
details
Curated
LIG_TYR_ITAM
CD3G_HUMAN
157
174
Avidity‑sensing
Phosphorylation of Y160 and Y171 in the ITAM motif of
T-cell surface glycoprotein CD3 gamma chain (CD3G)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase ZAP-70 (ZAP70)
.
details
Curated
LIG_TYR_ITAM
CD3G_HUMAN
157
174
Avidity‑sensing
Phosphorylation of Y160 and Y171 in the ITAM motif of
T-cell surface glycoprotein CD3 gamma chain (CD3G)
induces high-avidity binding to the tandem SH2 domains of
Tyrosine-protein kinase ZAP-70 (ZAP70)
.
details
Curated
