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Group by :Switch typeMotif classProteinEnzymePathway            Group Index    Colouring Info              Filtered: PFAM:PF01217 (16 hits) x
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  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
  Uncategorised  Rheostatic  Allostery  Avidity-sensing
  Physicochemical compatibility  Pre-translational  Competition

x  Index
Basal cell adhesion moleculeBeta-secretase 1CD44 antigen
Copper-transporting ATPase 1Delta-type opioid receptorEnvelope glycoprotein (Bovine)
HLA class II histocompatibility antigen gamma chainNef protein (Human)Niemann-Pick C1 protein
PEX5-related protein (Mus)Prolactin receptor (Rattus)Protein Nef (Human)
T-cell surface glycoprotein CD3 delta chain (Mus)T-cell surface glycoprotein CD3 gamma chain (Mus)T-cell surface glycoprotein CD4
VPS10 domain-containing receptor SorCS1


MotifStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

Basal cell adhesion molecule - BCAM -  Homo sapiens
TRG_LysEnd_APsAcLL_1604609BinaryAllosteryBinding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit sigma (AP2S1) subunit for recruitment of Basal cell adhesion molecule (BCAM) via an endocytosis motif.
details

Beta-secretase 1 - BACE1 -  Homo sapiens
TRG_LysEnd_APsAcLL_1495500BinaryAllosteryBinding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit sigma (AP2S1) subunit for recruitment of Beta-secretase 1 (BACE1) via an endocytosis motif.
details

CD44 antigen - CD44 -  Homo sapiens
TRG_LysEnd_APsAcLL_1708713BinaryAllosteryBinding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit sigma (AP2S1) subunit for recruitment of CD44 antigen (CD44) via an endocytosis motif.
details

Copper-transporting ATPase 1 - ATP7A -  Homo sapiens
TRG_LysEnd_APsAcLL_114831488BinaryAllosteryBinding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit sigma (AP2S1) subunit for recruitment of Copper-transporting ATPase 1 (ATP7A) via an endocytosis motif.
details

Delta-type opioid receptor - OPRD1 -  Homo sapiens
TRG_LysEnd_APsAcLL_1241246BinaryAllosteryBinding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit sigma (AP2S1) subunit for recruitment of Delta-type opioid receptor (OPRD1) via an endocytosis motif.
details

Envelope glycoprotein - env -  Bovine leukemia virus
TRG_LysEnd_APsAcLL_1463468BinaryAllosteryBinding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit sigma (AP2S1) subunit for recruitment of Envelope glycoprotein (env) via an endocytosis motif.
details

HLA class II histocompatibility antigen gamma chain - CD74 -  Homo sapiens
TRG_LysEnd_APsAcLL_11924BinaryAllosteryBinding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit sigma (AP2S1) subunit for recruitment of HLA class II histocompatibility antigen gamma chain (CD74) via an endocytosis motif.
details

Nef protein - nef -  Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)
TRG_LysEnd_APsAcLL_1160165BinaryAllosteryBinding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit sigma (AP2S1) subunit for recruitment of Nef protein (nef) via an endocytosis motif.
details

Niemann-Pick C1 protein - NPC1 -  Homo sapiens
TRG_LysEnd_APsAcLL_112711276BinaryAllosteryBinding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit sigma (AP2S1) subunit for recruitment of Niemann-Pick C1 protein (NPC1) via an endocytosis motif.
details

PEX5-related protein - Pex5l -  Mus musculus
TRG_LysEnd_APsAcLL_11419BinaryPre‑translationalAlternative splicing removes the di-leucine endocytosis motif of PEX5-related protein (Pex5l), abrogating binding to AP-2 complex subunit sigma (Ap2s1). The motif is present in exon 5.
details

Prolactin receptor - Prlr -  Rattus norvegicus
TRG_LysEnd_APsAcLL_1301306BinaryPre‑translationalAlternative splicing removes the di-leucine endocytosis motif of Prolactin receptor (Prlr), partially inhibiting binding to AP-2 complex subunit sigma (AP2S1) and the rate of endocytosis. Isoform Long of Prolactin receptor (Prlr) (also known as PRLR-long) has a longer C-terminal tail than the Isoform Short of Prolactin receptor (Prlr) (also known as PRLR-short) splice variant. PRLR-long internalises faster than PRLR-short due to two additional di-leucine motifs in the C-terminus (where the adjacent phenylalanine also plays a role). PRLR-short has two di-leucine motifs whereas PRLR-long has four.
details

Protein Nef - nef -  Human immunodeficiency virus type 1 group M subtype B (isolate BH8)
TRG_LysEnd_APsAcLL_1159164BinaryAllosteryBinding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit sigma (AP2S1) subunit for recruitment of Protein Nef (nef) via an endocytosis motif.
details

T-cell surface glycoprotein CD3 delta chain - Cd3d -  Mus musculus
TRG_LysEnd_APsAcLL_1138143BinaryAllosteryBinding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit sigma (Ap2s1) subunit for recruitment of T-cell surface glycoprotein CD3 delta chain (Cd3d) via an endocytosis motif.
details

T-cell surface glycoprotein CD3 gamma chain - Cd3g -  Mus musculus
TRG_LysEnd_APsAcLL_1149154BinaryAllosteryBinding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit sigma (Ap2s1) subunit for recruitment of T-cell surface glycoprotein CD3 gamma chain (Cd3g) via an endocytosis motif.
details

T-cell surface glycoprotein CD4 - CD4 -  Homo sapiens
TRG_LysEnd_APsAcLL_1434439BinaryAllosteryBinding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit sigma (AP2S1) subunit for recruitment of T-cell surface glycoprotein CD4 (CD4) via an endocytosis motif.
details

VPS10 domain-containing receptor SorCS1 - SORCS1 -  Homo sapiens
TRG_LysEnd_APsAcLL_211361140BinaryPre‑translationalAlternative splicing removes the di-leucine motif of Isoform 4 of VPS10 domain-containing receptor SorCS1 (SORCS1), abrogating binding to AP-2 complex subunit sigma (AP2S1). Human and mouse have completely different C-termini for SorCS1a (also known as Isoform 4 of VPS10 domain-containing receptor SorCS1 (SORCS1)), with only the human splice variant containing the motif.
details
           
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